BRCA1(Ser1280) Antibody, HRP Conjugated

• Catalog number
  bs-12884R-HRP
• Price
  Please ask
• Size
  0.1ml

• Long name
  BRCA1(Ser1280) Polyclonal Antibody, HRP Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  HRP
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  BRCA1Ser1280
• Specificity
  This is a highly specific antibody against BRCA1Ser1280.
• Modification
  Phosphorylation
• Modification site
  Ser1280
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1280
• Gene ID number
  672
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  BRCA1 phospho S1280; BRCA1 phospho Ser1280; p-BRCA1 phospho S280; BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
• Additional conjugation
  HRP Conjugated
• French translation
  anticorps

• Gene target
  BRCA1   Ser1280   Conjugated  
• Gene symbol
  BRCA1, BRCA1P1
• Short name
  Anti-BRCA1Ser1280
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  HRP
• Alternative name
  Anti-BRCA1Ser1280 PAb HRP
• Alternative technique
  antibodies
• Alternative to gene target
  breast cancer 1, early onset, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, BRCA1 and IDBG-52172 and ENSG00000012048 and 672, androgen receptor binding, nuclei, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120

Gene info

• Identity
  HGNC:1100
• Gene
  BRCA1
• Long gene name
  BRCA1 DNA repair associated
• Synonyms gene name
  • breast cancer 1, early onset
  • breast cancer 1
• Synonyms
  • RNF53
  • BRCC1
  • PPP1R53
  • FANCS
• Synonyms name
  • BRCA1/BRCA2-containing complex, subunit 1
  • protein phosphatase 1, regulatory subunit 53
  • Fanconi anemia, complementation group S
• GenBank acession
  • U14680
• Locus
  17q21.31
• Discovery year
  1991-02-20
• Entrez gene record
  672
• Pubmed identfication
  • 1676470
  • 25472942
• RefSeq identity
  • NM_007294
• Classification
  • Ring finger proteins
  • Protein phosphatase 1 regulatory subunits
  • BRCA1 A complex
  • BRCA1 B complex
  • BRCA1 C complex
  • FA complementation groups
• VEGA ID
  OTTHUMG00000157426
• Locus Specific Databases
  • Breast Cancer
  • Fanconi Anaemia Mutation Database
  • BRCA1 database at LOVD-China
  • Global Variome shared LOVD
  • LOVD - Leiden Open Variation Database
  • LRG_292

Gene info

• Identity
  HGNC:28470
• Gene
  BRCA1P1
• Long gene name
  BRCA1 pseudogene 1
• Synonyms
  • LBRCA1
  • PsiBRCA1
  • pseudo-BRCA1
• Synonyms name
  • like-BRCA1
• Locus
  17q21.31
• Discovery year
  2005-05-26
• Entrez gene record
  394269
• Pubmed identfication
  • 11880951
  • 8954804
  • 10205276
• RefSeq identity
  • NG_003183

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products