Teprenone, HSP70 Inducer

• Catalog number
  SIH-526-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  6809-52-5
• Description
  HSP70 Inducer
• Molecular weight
  330,6 g/mol
• Primary research fields
  Cancer, Heat Shock, Cell Signaling, Neuroscience
• Other name
  Geranylgeranylacetone, GGA, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
• Product category
  Small Molecules
• Product type
  Inducer
• Chemical formula
  C23H38O
• Origin
  Synthetic
• Purity pourcentage
  >95% (GC)
• Soluble in
  Soluble in DMSO (30 mg/ml)
• Physical appearance
  Colorless Oil
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  5282199
• Scientific context
  Teprenone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects) (1, 2). Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression (2). Other studies have shown that it induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice (3, 4).
• Bibliography
  1. Kobayashi T., Ohta Y., Yoshino J and Nakazawa S. (2001) Pharmacol Res. 43(1): 23-30. 2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530. 3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47. 4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.
• Release date
  12-Nov-2015
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Ferrostatin-1 (SIH-525), a Ferroptosis Inhibitor. CAS #: 347174-05-4. Molecular Formula: C15H22N2O2. Molecular Weight: 262.4 g/mol. Chemical structure of Ferrostatin-1, a Ferroptosis Inhibitor (SIH-525). CAS # 347174-05-4. Molecular Formula: C15H22N2O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products

• Gene target
  Teprenone   HSP70   Inducer  
• Gene symbol
  HSPA1B, HSPA14, HSPA1A, HSPA1L
• Short name
  Teprenone, HSP70 Inducer
• Alternative name
  Teprenone, HSP70 Inducer

Gene info

• Identity
  HGNC:5233
• Gene
  HSPA1B
• Long gene name
  heat shock protein family A (Hsp70) member 1B
• Synonyms gene name
  • heat shock 70kD protein 1B
  • heat shock 70kDa protein 1B
• Synonyms
  • HSP70-2
• Locus
  6p21.33
• Discovery year
  1995-08-11
• Entrez gene record
  3304
• Pubmed identfication
  • 1700760
• Classification
  • TIM23 complex
  • Heat shock 70kDa proteins
• VEGA ID
  OTTHUMG00000031202

Gene info

• Identity
  HGNC:29526
• Gene
  HSPA14
• Long gene name
  heat shock protein family A (Hsp70) member 14
• Synonyms gene name
  • heat shock 70kDa protein 14
• Synonyms
  • HSP70-4
  • HSP70L1
• GenBank acession
  • AF112210
• Locus
  10p13
• Discovery year
  2004-04-20
• Entrez gene record
  51182
• Pubmed identfication
  • 21208456
• RefSeq identity
  • NM_016299
• Classification
  • Heat shock 70kDa proteins

Gene info

• Identity
  HGNC:5232
• Gene
  HSPA1A
• Long gene name
  heat shock protein family A (Hsp70) member 1A
• Synonyms gene
  • HSPA1
• Synonyms gene name
  • heat shock 70kD protein 1A
  • heat shock 70kDa protein 1A
• Synonyms
  • HSP70-1
• GenBank acession
  • BC002453
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  3303
• Classification
  • TIM23 complex
  • Heat shock 70kDa proteins
• VEGA ID
  OTTHUMG00000031201

Gene info

• Identity
  HGNC:5234
• Gene
  HSPA1L
• Long gene name
  heat shock protein family A (Hsp70) member 1 like
• Synonyms gene name
  • heat shock 70kD protein-like 1
  • heat shock 70kDa protein 1-like
• Synonyms
  • HSP70-HOM
  • hum70t
• GenBank acession
  • D85730
• Locus
  6p21.33
• Discovery year
  1989-05-12
• Entrez gene record
  3305
• Pubmed identfication
  • 9685725
  • 9349405
• Classification
  • TIM23 complex
  • Heat shock 70kDa proteins
• VEGA ID
  OTTHUMG00000031208

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