anti- LAMB1 antibody

• Catalog number
  FNab04678
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
• Immunogen
  laminin, beta 1
• Calculated MW
  198 kDa
• Uniprot ID
  P07942
• Specificity
  Human, Mouse
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:1000 - 1:4000; IHC: 1:100 - 1:200
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LAMB1  
• Gene symbol
  LAMB1
• Short name
  anti- LAMB1 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- laminin, b 1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  laminin, beta 1, CLM and LIS5, LAMB1 and IDBG-35838 and ENSG00000091136 and 3912, glycosphin this GO lipid binding, Extracellular, Lamb1 and IDBG-132841 and ENSMUSG00000002900 and 16777, LAMB1 and IDBG-632390 and ENSBTAG00000011412 and 520030

Gene info

• Identity
  HGNC:6486
• Gene
  LAMB1
• Long gene name
  laminin subunit beta 1
• Synonyms gene
  • CLM
• Synonyms gene name
  • cutis laxa with marfanoid phenotype
  • laminin, beta 1
• GenBank acession
  • M61916
• Locus
  7q31.1
• Discovery year
  1986-01-01
• Entrez gene record
  3912
• Pubmed identfication
  • 2563160
  • 2704655
  • 1864606
• RefSeq identity
  • NM_002291
• Classification
  • Laminin subunits
• VEGA ID
  OTTHUMG00000149966

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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