Lin28-TAT, Human Recombinant
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Catalog numberP1010-20
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PricePlease ask
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Size20 ug
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SynonymsCSDD1, LIN28A, ZCCHC1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1
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Alternative_namesCSDD1, LIN28A, ZCCHC1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1
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DescriptionTranslational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis.
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Purity≥95%
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Endotoxin Level< 1 EU/ug
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Molecular Weight24.4 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceDry powder
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Physical form descriptionLyophilized powder
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Reconstitution InstructionsReconstitute in sterile deionized water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
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Background InformationTranslational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells.
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Amino acid sequenceFull length human Lin28 with 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR)
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolTAT, TAT-AS1, HTATSF1, HTATSF1P1, TRI-TAT2-2, TRI-TAT1-1, TRI-TAT3-1, TRI-TAT2-3, TRI-TAT2-1
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Short nameLin28-TAT, Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameLin28-TAT, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nametyrosine aminotransferase
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Locus
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Discovery year2001-06-22
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTAT antisense RNA 1
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GenBank acession
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Locus
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Discovery year2014-10-16
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Entrez gene record
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHIV-1 Tat specific factor 1
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Synonyms gene name
- HIV TAT specific factor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-07-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RNA binding motif containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameHIV-1 Tat specific factor 1 pseudogene 1
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Synonyms gene
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Synonyms gene name
- HIV TAT specific factor 1 pseudogene
- HIV-1 Tat specific factor 1 pseudogene
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Synonyms
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Locus
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Discovery year2003-11-26
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametRNA-Ile (anticodon TAT) 2-2
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Synonyms gene
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Synonyms gene name
- transfer RNA isoleucine 2 (anticodon UAU)
- transfer RNA-Ile (TAT) 2-2
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Ile (anticodon TAT) 1-1
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Synonyms gene
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Synonyms gene name
- transfer RNA isoleucine 18 (anticodon UAU)
- transfer RNA-Ile (TAT) 1-1
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Ile (anticodon TAT) 3-1
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Synonyms gene
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Synonyms gene name
- transfer RNA isoleucine 21 (anticodon UAU)
- transfer RNA-Ile (TAT) 3-1
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Ile (anticodon TAT) 2-3
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Synonyms gene
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Synonyms gene name
- transfer RNA isoleucine 6 (anticodon UAU)
- transfer RNA-Ile (TAT) 2-3
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Ile (anticodon TAT) 2-1
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Synonyms gene
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Synonyms gene name
- transfer RNA isoleucine 13 (anticodon UAU)
- transfer RNA-Ile (TAT) 2-1
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
