TY-52156

Alternative_name

N-(4-Chlorophenyl)-3,3-dimethyl
Description

TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.
CAS Number

934369-14-9
Structure Available

Yes
Molecular Formula

C₁₈H₁₉Cl₂N₃O
Molecular Weight

364.27
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>35 mg/ml) or EtOH (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A novel S1P3 receptor antagonist
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

16046248
PubChem CID Link
SMILES

CC(C)(C)C(=O)C(=NC1=CC=C(C=C1)Cl)NNC2=CC=C(C=C2)Cl
InChi

InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
InChi Key

XONRRGIRSGNWFP-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes