anti-BMP-4 Antibody [3H2]
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Catalog number38-231
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PricePlease ask
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Size0.5 mg
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Gene infoBMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.
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Gene namesBone morphogenetic protein, BMP2B, DVR4, Bone morphogenetic protein 4, Bone morphogenetic protein 2B, BMP-4, ZYME, OFC11, BMP2B1, MCOPS6
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Antibodie s labelunlabelled serum
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PurityThis IgG2bK antibody was purified from cell culture by Protein G affinity chromatography.
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Ab raised inMouse
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TypeMonoclonal
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Monoclonal3H2
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AntigenBMP-4 antibody is produced in mice using highly pure (>98%) recombinant human BMP-4 as the immunizing antigen.
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Immuno applicationELISA, Western Blot, NELISAut
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Antibody adviceNeutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hBMP-4 (5.0 ng/mL), a concentration of 0.4-0.6 ug/mL of this antibody is required.ELISA:In a sandwich ELISA (assuming 100 μL/well), a concentration of 4.0-8.0 ug/mL of this antibody will detect at least 2000 pg/mL of recombinant human BMP-4 when used in conjunction with compatible secondary reagents. Western Blot:To detect hBMP-4 by Western Blot analysis this antibody can be used at a concentration of 0.25-0.50 ug/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBMP-4 is 2.0-4.0 ng/lane, under non-reducing conditions.
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Keep atBMP-4 lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 grades C. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/mL. The antibody is stable for at least six weeks at 2-4 grades C when reconstituted.
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Works withHuman
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Omim nr115073
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Ncbi nrP12644
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Vial with antibodyLyophilized
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NCBI GENE nr652
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GENE symbolBMP4
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Antigene namebone morphogenetic protein 4
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SourceHomo sapiens
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Protein nrP12644
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolBMP4, GDF11, GDF10, BMP1, GDF2, MIR1302-4, PIRC18, PIRC16
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Short nameanti-BMP-4 Antibody [3H2]
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toBMP-4 (antibody to-) [3H2]
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namebone morphogenetic protein 4
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Synonyms gene
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GenBank acession
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Locus
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Discovery year1990-06-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Bone morphogenetic proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegrowth differentiation factor 11
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-12-02
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Entrez gene record
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Pubmed identfication
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Classification
- Transforming growth factor beta superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegrowth differentiation factor 10
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-09-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Transforming growth factor beta superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namebone morphogenetic protein 1
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Synonyms gene
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Synonyms gene name
- procollagen C-endopeptidase
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Synonyms
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Synonyms name
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Locus
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Discovery year1990-06-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Bone morphogenetic proteins
- Astacins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegrowth differentiation factor 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-09-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Transforming growth factor beta superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-4
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 18
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 16
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
