TC-S 7010

• Catalog number
  B1203-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
• Description
  TC-S 7010 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 3.4 nM). It displays1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC₅₀ values are 0.19 and 2.9 μM respectively).
• CAS Number
  1158838-45-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₁H₃₁ClFN₇O₂
• Molecular Weight
  588.07
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective inhibitor of Aurora kinase A
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44139710
• PubChem CID Link
• SMILES
  CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F
• InChi
  InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-2
• InChi Key
  AKSIZPIFQAYJGF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TC-S   7010  
• Gene symbol
  MT-TC, TCOF1, B3GAT2, CD55, PTPN2, HLA-S, CTSL3P, STRN3, TCIM, RAC1
• Short name
  TC-S 7010
• Alternative name
  TC-S 7010

Gene info

• Identity
  HGNC:7477
• Gene
  MT-TC
• Long gene name
  mitochondrially encoded tRNA-Cys (UGU/C)
• Synonyms gene
  • MTTC
• Synonyms gene name
  • tRNA cysteine
  • mitochondrially encoded tRNA cysteine
• Synonyms
  • trnC
• Locus
  mitochondria
• Discovery year
  1989-10-12
• Entrez gene record
  4511
• Pubmed identfication
  • 7219534
• Classification
  • Mitochondrially encoded transfer RNAs

Gene info

• Identity
  HGNC:11654
• Gene
  TCOF1
• Long gene name
  treacle ribosome biogenesis factor 1
• Synonyms gene name
  • Treacher Collins-Franceschetti syndrome 1
• Synonyms
  • treacle
  • TCS
• Locus
  5q32-q33.1
• Discovery year
  1991-05-21
• Entrez gene record
  6949
• Pubmed identfication
  • 1765376
• RefSeq identity
  • NM_001008656
• Classification
  • Ribosomal biogenesis factors
• VEGA ID
  OTTHUMG00000130081
• Locus Specific Databases
  • LOVD TCOF1 mutation database

Gene info

• Identity
  HGNC:922
• Gene
  B3GAT2
• Long gene name
  beta-1,3-glucuronyltransferase 2
• Synonyms
  • GlcAT-S
• Synonyms name
  • glucuronosyltransferase S
  • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
• GenBank acession
  • AB075843
• Locus
  6q13
• Discovery year
  2000-01-07
• Entrez gene record
  135152
• Pubmed identfication
  • 12383500
• RefSeq identity
  • NM_080742
• Classification
  • Beta-1,3-glucuronyltransferases
• VEGA ID
  OTTHUMG00000014997

Gene info

• Identity
  HGNC:2665
• Gene
  CD55
• Long gene name
  CD55 molecule (Cromer blood group)
• Synonyms gene
  • DAF
• Synonyms gene name
  • decay accelerating factor for complement (CD55, Cromer blood group system)
  • CD55 molecule, decay accelerating factor for complement (Cromer blood group)
• Synonyms
  • CR
  • TC
  • CROM
• GenBank acession
  • BC001288
• Locus
  1q32.2
• Discovery year
  2001-06-22
• Entrez gene record
  1604
• RefSeq identity
  • NM_000574
• Classification
  • Blood group antigens
  • Complement system regulators and receptors
  • CD molecules
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000036255
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • CD55base: Mutation registry for Decay-accelerating factor (CD55) deficiency (previously known as DAFbase)
  • LRG_127

Gene info

• Identity
  HGNC:9650
• Gene
  PTPN2
• Long gene name
  protein tyrosine phosphatase non-receptor type 2
• Synonyms gene
  • PTPT
• Synonyms
  • TCELLPTP
  • TC-PTP
  • TCPTP
• GenBank acession
  • M25393
• Locus
  18p11.21
• Discovery year
  1991-09-13
• Entrez gene record
  5771
• Pubmed identfication
  • 2164224
• RefSeq identity
  • NM_002828
  • NM_080422
  • NM_080423
• Classification
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000131702

Gene info

• Identity
  HGNC:19395
• Gene
  HLA-S
• Long gene name
  major histocompatibility complex, class I, S (pseudogene)
• Synonyms
  • HLA-17
• GenBank acession
  • M96339
• Locus
  6p21.33
• Discovery year
  2002-10-23
• Entrez gene record
  267015
• Pubmed identfication
  • 10452889
  • 1517563
• RefSeq identity
  • NG_009941
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031178
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:33132
• Gene
  CTSL3P
• Long gene name
  cathepsin L family member 3, pseudogene
• Synonyms gene
  • CTSL3
• Synonyms gene name
  • cathepsin L family member 3
• Synonyms
  • HCTSL-s
• GenBank acession
  • AJ851862
• Locus
  9q21.33
• Discovery year
  2007-04-27
• Entrez gene record
  392360
• Pubmed identfication
  • 19663681
• RefSeq identity
  • NR_027917
• VEGA ID
  OTTHUMG00000020152

Gene info

• Identity
  HGNC:15720
• Gene
  STRN3
• Long gene name
  striatin 3
• Synonyms gene name
  • striatin, calmodulin binding protein 3
• Synonyms
  • SG2NA
  • PPP2R6B
  • S/G2NA
• Synonyms name
  • cell cycle S/G2 nuclear autoantigen
  • protein phosphatase 2 regulatory subunit B'''beta
• Locus
  14q12
• Discovery year
  2002-07-22
• Entrez gene record
  29966
• Pubmed identfication
  • 7864889
  • 10681496
• RefSeq identity
  • NM_014574
• Classification
  • WD repeat domain containing
  • STRIPAK complex
  • Protein phosphatase 2 regulatory subunits
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000140201

Gene info

• Identity
  HGNC:1357
• Gene
  TCIM
• Long gene name
  transcriptional and immune response regulator
• Synonyms gene
  • C8orf4
• Synonyms gene name
  • chromosome 8 open reading frame 4
• Synonyms
  • TC-1
  • hTC-1
  • TC1
• Synonyms name
  • human thyroid cancer 1
• GenBank acession
  • AF268037
• Locus
  8p11.21
• Discovery year
  2000-07-12
• Entrez gene record
  56892
• Pubmed identfication
  • 11056052
  • 24937306
• RefSeq identity
  • NM_020130
• VEGA ID
  OTTHUMG00000164045

Gene info

• Identity
  HGNC:9801
• Gene
  RAC1
• Long gene name
  Rac family small GTPase 1
• Synonyms gene name
  • ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
• Synonyms
  • TC-25
  • p21-Rac1
  • Rac-1
• GenBank acession
  • AJ132695
• Locus
  7p22.1
• Discovery year
  1993-11-05
• Entrez gene record
  5879
• Pubmed identfication
  • 2674130
  • 10597294
• RefSeq identity
  • NM_018890
• Classification
  • Rho family GTPases
  • Receptor ligands
• VEGA ID
  OTTHUMG00000023540

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