Bcl-2
-
Catalog numberGEN438456
-
PricePlease ask
-
Size100ug
-
-
Also known asBcl-2
-
Other namesapoptosis regulator Bcl-2 alpha isoform; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2; N/A
-
CategoryAntibodies
-
SubcategoryMnoclonal antibodies
-
Gene nameBCL2
-
Gene name synonimsN/A
-
Other gene namesBCL2; BCL2; Bcl-2; PPP1R50; N/A
-
ClonalityMonoclonal
-
Immunoglobulin isotypeIgG1, kappa
-
Clone124
-
Host organismMouse (Mus musculus)
-
Species reactivityHuman (Homo sapiens). Does not react with Mouse (Mus musculus) and Rat (Rattus norvegicus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
-
Specificity and cross reactivityThis antibody recognizes a protein of 25-26kDa, identified as the bcl-2?lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2?lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2?lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
-
Purification methodN/A
-
Form AppearanceN/A
-
ConcentrationN/A
-
Storage and shippingStore the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
-
Tested applicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
-
Gene target
-
Gene symbolN4BP2, C20orf144, BCL2L2
-
Short nameBcl-2
-
Alternative nameAnti-Bcl-2
-
Gene info
-
Identity
-
Gene
-
Long gene nameNEDD4 binding protein 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2008-01-18
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namechromosome 20 open reading frame 144
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-07-17
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameBCL2 like 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1997-07-22
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- BCL2 family
- Protein phosphatase 1 regulatory subunits
-
VEGA ID