Bcl-2

• Catalog number
  GEN438175
• Price
  Please ask
• Size
  100ug

• Also known as
  Bcl-2
• Other names
  apoptosis regulator Bcl-2 alpha isoform; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50; B-cell CLL/lymphoma 2; N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  BCL2
• Gene name synonims
  N/A
• Other gene names
  BCL2; BCL2; Bcl-2; PPP1R50; N/A
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1, kappa (100/D5) + IgG1, kappa (124)
• Clone
  100/D5+124
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens). Does not react with Mouse (Mus musculus) and Rat (Rattus norvegicus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  This antibody recognizes a protein of 25-26kDa, identified as the bcl-2?lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2?lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2?lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

• Gene target
  Bcl-2  
• Gene symbol
  N4BP2, C20orf144, BCL2L2
• Short name
  Bcl-2
• Alternative name
  Anti-Bcl-2

Gene info

• Identity
  HGNC:29851
• Gene
  N4BP2
• Long gene name
  NEDD4 binding protein 2
• Synonyms
  • B3BP
• Synonyms name
  • BCL-3 binding protein
• GenBank acession
  • AB037834
• Locus
  4p14
• Discovery year
  2008-01-18
• Entrez gene record
  55728
• Pubmed identfication
  • 10718198
  • 11717310
• RefSeq identity
  • NM_018177
• VEGA ID
  OTTHUMG00000128599

Gene info

• Identity
  HGNC:16137
• Gene
  C20orf144
• Long gene name
  chromosome 20 open reading frame 144
• Synonyms
  • dJ63M2.6
  • bclt
• Synonyms name
  • bcl-2-like protein from testis
• GenBank acession
  • AL121906
• Locus
  20q11.22
• Discovery year
  2001-07-17
• Entrez gene record
  128864
• Pubmed identfication
  • 11780052
• RefSeq identity
  • NM_080825
• VEGA ID
  OTTHUMG00000032263

Gene info

• Identity
  HGNC:995
• Gene
  BCL2L2
• Long gene name
  BCL2 like 2
• Synonyms
  • KIAA0271
  • BCL-W
  • PPP1R51
• Synonyms name
  • protein phosphatase 1, regulatory subunit 51
• GenBank acession
  • D87461
• Locus
  14q11.2
• Discovery year
  1997-07-22
• Entrez gene record
  599
• Pubmed identfication
  • 8761287
• RefSeq identity
  • NM_004050
• Classification
  • BCL2 family
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000028738

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