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Target antigen
Smad3
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Smad3 (193-222aa DHQMNHSMDAGSPNLSPNPMSPAHNNLDLQ), identical to the related mouse and rat sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Smad3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Smad3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins. It is located in 15q22.33. And it mediates the signals from the transforming growth factor beta (TGF-β) super family ligands that regulate cell proliferation, differentiation and death. Based on its essential role in TGF beta signaling pathway, SMAD3 has been related with tumor growth in cancer development.
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Related articles
1. "Entrez Gene: SMAD3 SMAD family member 3". 2. Moustakas A, Souchelnytskyi S, Heldin CH (2001). "Smad regulation in TGF-beta signal transduction". J. Cell. Sci. 114 (Pt 24): 4359–69. 3. Zhang Y, Feng X, We R, Derynck R (September 1996). "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response". Nature 383 (6596): 168–72.
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Gene Name
SMAD3
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Protein Name
Mothers against decapentaplegic homolog 3
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Gene Full Name
SMAD family member 3
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Synonyms
DKFZP586N0721 antibody|DKFZp686J10186 antibody|hMAD 3 antibody|hMAD-3 antibody|hSMAD3 antibody|HSPC193 antibody|HST17436 antibody|JV15 2 antibody|JV15-2 antibody|JV152 antibody|JV152 antibody|LDS1C antibody|LDS3 antibody|MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody|MAD (mothers against decapentaplegic Drosophila) homolog 3 antibody|MAD homolog 3 antibody|Mad homolog JV15 2 antibody|Mad protein homolog antibody|MAD, mothers against decapentaplegic homolog 3 antibody|MAD3 antibody|MAD3 antibody|MADH 3 antibody|MADH3 antibody|MADH3 antibody|MGC60396 antibody|Mothers against decapentaplegic homolog 3 antibody|Mothers against DPP homolog 3 antibody|Mothers against DPP homolog 3 antibody|SMA and MAD related protein 3 antibody|SMAD 3 antibody|SMAD antibody|SMAD family member 3 antibody|SMAD, mothers against DPP homolog 3 antibody|SMAD3 antibody|SMAD3_HUMAN antibody
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Uniprot ID
P84022
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Entrez GeneID
4088
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
