Human CellExp™ LRRC32 / GARP, Fc Tag, Human Recombinant

• Catalog number
  P1207-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant
• Alternative_names
  GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant
• Description
  Binds to TGF-beta to suppress naïve T cell proliferation.
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  > 95%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per/ug
• Activity Specifications test method
  Measured by its binding ability in a functional ELISA.
• Biological activity
  Immobilized Latent TGFB1, N-His at 5 ug/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 ug/mL.
• Binding Capacity
  Immobilized Latent TGFB1, N-His at 5 ug/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 ug/mL.
• Molecular Weight
  92.6 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Reconstitute in sterile deionized water to the desired protein concentration.
• Background Information
  Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   LRRC32   GARP   Tag  
• Gene symbol
  LRRC32, SH3BGR, CNGB1
• Short name
  CellExp™ LRRC32 / GARP, Fc Tag, Recombinant
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ LRRC32 / GARP, fragment c detection labelled, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:4161
• Gene
  LRRC32
• Long gene name
  leucine rich repeat containing 32
• Synonyms gene
  • D11S833E
  • GARP
• Synonyms gene name
  • glycoprotein A repetitions predominant
• GenBank acession
  • Z24680
• Locus
  11q13.5
• Discovery year
  1994-12-15
• Entrez gene record
  2615
• Pubmed identfication
  • 8180135
  • 1543912
• RefSeq identity
  • NM_005512
• VEGA ID
  OTTHUMG00000133687

Gene info

• Identity
  HGNC:10822
• Gene
  SH3BGR
• Long gene name
  SH3 domain binding glutamate rich protein
• Synonyms gene name
  • SH3 domain binding glutamic acid-rich protein
  • SH3 domain binding glutamate-rich protein
• Synonyms
  • 21-GARP
• Synonyms name
  • 21-glutamic acid-rich protein
• Locus
  21q22.2
• Discovery year
  1996-10-11
• Entrez gene record
  6450
• Pubmed identfication
  • 9050928
• RefSeq identity
  • NM_007341
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000074113

Gene info

• Identity
  HGNC:2151
• Gene
  CNGB1
• Long gene name
  cyclic nucleotide gated channel subunit beta 1
• Synonyms gene
  • CNCG2
  • CNCG3L
• Synonyms gene name
  • cyclic nucleotide gated channel beta 1
• Synonyms
  • RCNC2
  • RCNCb
  • GARP
  • GAR1
  • CNGB1B
  • RP45
• Synonyms name
  • glutamic acid-rich protein
  • cyclic nucleotide-gated cation channel beta-1
• GenBank acession
  • AF042498
• Locus
  16q21
• Discovery year
  1994-12-20
• Entrez gene record
  1258
• Pubmed identfication
  • 8766832
  • 7590744
  • 16382102
• RefSeq identity
  • NM_001297
• Classification
  • Cyclic nucleotide gated channels
• VEGA ID
  OTTHUMG00000154810

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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