SW-033291

• Catalog number
  9584-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine;SW033291
• Description
  SW-033291 is a potent inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) (Ki = ~0.1 nM). It rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection. SW033291 accelerates hematopoietic recovery in mice receiving bone marrow transplant and promotes tissue regeneration in mouse models of colon and liver injury.
• CAS Number
  459147-39-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₀N₂OS₃
• Molecular Weight
  412.58
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent 15-PGDH (15-hydroxy prostaglandin dehydrogenase) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  3337839
• PubChem CID Link
• SMILES
  CCCCS(=O)C1=C(C2=C(S1)N=C(C=C2C3=CC=CC=C3)C4=CC=CS4)N
• InChi
  InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
• InChi Key
  LCYAYKSMOVLVRL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SW-033291  
• Gene symbol
  TUBB, MEX3D, SLC4A1, CDK5RAP3
• Short name
  SW-033291
• Alternative name
  SW-033291

Gene info

• Identity
  HGNC:20778
• Gene
  TUBB
• Long gene name
  tubulin beta class I
• Synonyms gene name
  • tubulin, beta polypeptide
  • tubulin, beta
  • tubulin, beta class I
• Synonyms
  • OK/SW-cl.56
  • MGC16435
  • M40
  • Tubb5
• Synonyms name
  • class I beta-tubulin
  • beta1-tubulin
• GenBank acession
  • AB062393
• Locus
  6p21.33
• Discovery year
  2004-11-22
• Entrez gene record
  203068
• Pubmed identfication
  • 11504633
  • 8270253
• RefSeq identity
  • NM_178014
• Classification
  • Tubulins
• VEGA ID
  OTTHUMG00000031059

Gene info

• Identity
  HGNC:16734
• Gene
  MEX3D
• Long gene name
  mex-3 RNA binding family member D
• Synonyms gene
  • RKHD1
• Synonyms gene name
  • ring finger and KH domain containing 1
  • mex-3 homolog D (C. elegans)
• Synonyms
  • Tino
  • KIAA2031
  • OK/SW-cl.4
  • RNF193
• Synonyms name
  • bcl-2 ARE RNA binding protein
• GenBank acession
  • AB107353
• Locus
  19p13.3
• Discovery year
  2004-03-17
• Entrez gene record
  399664
• Pubmed identfication
  • 17267406
• RefSeq identity
  • NM_203304
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000150369

Gene info

• Identity
  HGNC:11027
• Gene
  SLC4A1
• Long gene name
  solute carrier family 4 member 1 (Diego blood group)
• Synonyms gene
  • EPB3
  • AE1
  • DI
  • WD
• Synonyms gene name
  • Waldner blood group
  • erythrocyte membrane protein band 3
  • Diego blood group
  • solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
  • solute carrier family 4 (anion exchanger), member 1
  • solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
• Synonyms
  • RTA1A
  • CD233
  • FR
  • SW
  • WR
• Synonyms name
  • Froese blood group
  • Swann blood group
  • Wright blood group
• Locus
  17q21.31
• Discovery year
  1988-04-20
• Entrez gene record
  6521
• Pubmed identfication
  • 8434259
• RefSeq identity
  • NM_000342
• Classification
  • Blood group antigens
  • Solute carriers
  • CD molecules
• VEGA ID
  OTTHUMG00000156843
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_803

Gene info

• Identity
  HGNC:18673
• Gene
  CDK5RAP3
• Long gene name
  CDK5 regulatory subunit associated protein 3
• Synonyms
  • MST016
  • FLJ13660
  • C53
  • IC53
  • HSF-27
  • OK/SW-cl.114
  • LZAP
• Synonyms name
  • ischemic heart CDK5 activator-binding protein C53
  • LXXLL/leucine-zipper-containing ARFbinding protein
• GenBank acession
  • AF110322
• Locus
  17q21.32
• Discovery year
  2002-07-22
• Entrez gene record
  80279
• Pubmed identfication
  • 10721722
• RefSeq identity
  • NM_176096
• VEGA ID
  OTTHUMG00000178682

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