MI-2
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Catalog numberB1835-25
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PricePlease ask
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Size25 mg
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Alternative_name4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine; Menin-MLL inhibitor 2
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DescriptionMI-2 is a Menin-MLL (Mixed linage leukemia) protein interaction inhibitor with an IC₅₀ of 0.45 μM. MLL protein is a histone methyltransferase that positively regulates gene transcription. However, MLL gene is a common target for chromosomal translocations found in some leukemia.
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CAS Number1271738-62-5
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Structure AvailableYes
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Molecular FormulaC₁₈H₂₅N₅S₂
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Molecular Weight375.55
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>15 mg/ml)
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HandlingProtect from air and light
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Tag LineA Menin-MLL (Mixed linage leukemia) protein interaction inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID54765302
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SMILESCCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C
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InChiInChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
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InChi KeySRQYLNYQAPCPIR-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolCHD4, CHD3, MITF, MIER1, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2
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Short nameMI-2
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Alternative nameMI-2
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Gene info
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Identity
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Gene
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Long gene namechromodomain helicase DNA binding protein 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NuRD complex subunits
- PHD finger proteins
- Small nucleolar RNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namechromodomain helicase DNA binding protein 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNA protein coding host genes
- NuRD complex subunits
- PHD finger proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemelanocyte inducing transcription factor
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Synonyms gene
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Synonyms gene name
- Waardenburg syndrome, type 2A
- microphthalmia-associated transcription factor
- melanogenesis associated transcription factor
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-10-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic helix-loop-helix proteins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameMIER1 transcriptional regulator
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Synonyms gene name
- mesoderm induction early response 1 homolog (Xenopus laevis)
- mesoderm induction early response 1, transcriptional regulator
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Synonyms
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Locus
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Discovery year2005-07-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Myb/SANT domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1289-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1289 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 521-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR515 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 512-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 7-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR7 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 329-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-11
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR329 family