Ganetespib (STA-9090)

Alternative_name

5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H- 1,2,4-triazol-3-one
Description

Ganetespib (STA-9090) is a non-Geldanamycin, selective Hsp90 inhibitor that displays antineoplastic activity. downregulates VEGFR, c-MET, HER2, IGF-IR, EGFR, and other Hsp90 client proteins involved in hepatocarcinogenesis, thereby making it an attractive therapy for hepatocellular carcinoma.
CAS Number

888216-25-9
Structure Available

Yes
Molecular Formula

C₂₀H₂₀N₄O₃
Molecular Weight

364.4
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A potent, Hsp90 inhibitor
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

36 months
MDL Number

MFCD22420818
PubChem CID

23624255
PubChem CID Link
SMILES

CC(C)C1=CC(=C2NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)C(=O)C=C1O
InChi

InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,21,25H,1-3H3,(H,22,27)/b19-15+
InChi Key

MWTUOSWPJOUADP-XDJHFCHBSA-N
Data Sheet Link
MSDS Available

Yes