Leptomycin B

Alternative_name

LMB; Elactocin; Mantuamycin; CI-940; CL-1957A; PD-114720; ATS 1287B
Description

A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53.
CAS Number

87081-35-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₃H₄₈O₆
Molecular Weight

540.73
Cell Permeable

Yes
Purity

≥99% by HPLC
Handling

Protect from air and light
Tag Line

An inhibitor of nuclear export
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD06795848
PubChem CID

6917907
PubChem CID Link
SMILES

CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
InChi

InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+, 21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
InChi Key

YACHGFWEQXFSBS-XYERBDPFSA-N
Data Sheet Link
MSDS Available

Yes