Alpelisib

• Catalog number
  B1271-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; BYL719
• Description
  Alpelisib (also known as BYL719), is a potent and selective phosphatidylinositol-3 kinase α inhibitor. It inhibits P110α, p110β, p110δ, and p110g with IC₅₀ values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibits the Akt phosphorylation with IC₅₀ values of 74 nM in Rat1-myr-p110α cells, 2.2 µM in Rat1-myr-p110β cells, and 1.2 µM in Rat1-myr-p110δ cells.
• CAS Number
  1217486-61-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₂F₃N₅O₂S
• Molecular Weight
  441.47
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective phosphatidylinositol-3 kinase α inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  56649450
• PubChem CID Link
• SMILES
  CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
• InChi
  InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1
• InChi Key
  STUWGJZDJHPWGZ-LBPRGKRZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Alpelisib  
• Short name
  Alpelisib
• Alternative name
  Alpelisib

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