BMS-911543

• Catalog number
  2630-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide ; BMS911543
• Description
  BMS-911543 is a potent and selective JAK2 inhib itor. It displays potent anti-proliferative and pharmacodynamic effects in cell lines dependent upon JAK2 signaling, and has little activity in cell types dependent upon other pathways, such as JAK1 and JAK3. In addition, it displays anti-proliferative responses in colony growth assays using primary progenitor cells isolated from patients with JAK2(V617F)-positive myeloproliferative neoplasms (MPNs).
• CAS Number
  1271022-90-2
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₈N₈O
• Molecular Weight
  432.52
• Cell Permeable
  Yes
• Purity
  >98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective JAK2 inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  50922691
• PubChem CID Link
• SMILES
  CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6
• InChi
  nChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)
• InChi Key
  JCINBYQJBYJGDM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BMS-911543  
• Short name
  BMS-911543
• Alternative name
  BMS-911543

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