CD74
-
Catalog numberGEN438239
-
PricePlease ask
-
Size100ug
-
-
Also known asCD74
-
Other namesN/A; N/A; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; N/A
-
CategoryAntibodies
-
SubcategoryMnoclonal antibodies
-
Gene nameCD74
-
Gene name synonimsN/A
-
Other gene namesCD74; N/A; II; DHLAG; HLADG; Ia-GAMMA; N/A
-
ClonalityMonoclonal
-
Immunoglobulin isotypeIgG1, kappa
-
CloneSPM523
-
Host organismMouse (Mus musculus)
-
Species reactivityHuman (Homo sapiens), Mouse (Mus musculus).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
-
Specificity and cross reactivityCD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
-
Purification methodN/A
-
Form AppearanceN/A
-
ConcentrationN/A
-
Storage and shippingStore the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
-
Tested applicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
-
Gene target
-
Gene symbolCD74
-
Short nameCD74
-
Alternative nameAnti-CD74
-
Alternative to gene targetCD74 molecule, major histocompatibility complex, class II invariant chain, DHLAG and HLADG and Ia-GAMMA and II, CD74 and IDBG-53594 and ENSG00000019582 and 972, MHC class II protein binding, Cell surfaces, Cd74 and IDBG-150302 and ENSMUSG00000024610 and 16149, BT.46809 and IDBG-646288 and ENSBTAG00000015228 and 613384
-
Gene info
-
Identity
-
Gene
-
Long gene nameCD74 molecule
-
Synonyms gene
-
Synonyms gene name
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
- CD74 molecule, major histocompatibility complex, class II invariant chain
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year1986-01-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- CD molecules
-
VEGA ID