Doublecortin Antibody

• Catalog number
  A01053-1
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Doublecortin
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human Doublecortin (74-100aa QSLRFHQNMELDFGHFDERDKTSRNMR).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Doublecortin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Doublecortin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X, is a protein that in humans is encoded by the DCX gene. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
• Related articles
  1. Brown JP, Couillard-Després S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG (December 2003). "Transient expression of doublecortin during adult neurogenesis". J. Comp. Neurol. 467 (1): 1–10. 2. Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, Bogdahn U, Winkler J, Kuhn HG, Aigner L (January 2005). "Doublecortin expression levels in adult brain reflect neurogenesis".Eur. J. Neurosci. 21 (1): 1–14.
• Gene Name
  DCX
• Protein Name
  Neuronal migration protein doublecortin
• Gene Full Name
  doublecortin
• Synonyms
  DBCN | Dbct | DC | DCX | Doublecortex | Doublin | Lis X | Lis-X | Lissencephalin X | Lissencephalin-X | LISX | SCLH | XLIS | O43602
• Uniprot ID
  O43602
• Entrez GeneID
  1641
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Doublecortin  
• Gene symbol
  DCLK3, DCLK1, DCDC1
• Short name
  Doublecortin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Doublecortin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:19005
• Gene
  DCLK3
• Long gene name
  doublecortin like kinase 3
• Synonyms gene
  • DCAMKL3
• Synonyms gene name
  • doublecortin and CaM kinase-like 3
  • doublecortin-like kinase 3
• Synonyms
  • KIAA1765
  • DCDC3C
• GenBank acession
  • AB051552
• Locus
  3p22.2
• Discovery year
  2005-01-20
• Entrez gene record
  85443
• Pubmed identfication
  • 11214970
  • 16869982
• RefSeq identity
  • NM_033403
• Classification
  • Doublecortin superfamily
• VEGA ID
  OTTHUMG00000155805

Gene info

• Identity
  HGNC:2700
• Gene
  DCLK1
• Long gene name
  doublecortin like kinase 1
• Synonyms gene
  • DCAMKL1
• Synonyms gene name
  • doublecortin and CaM kinase-like 1
  • doublecortin-like kinase 1
• Synonyms
  • KIAA0369
  • DCLK
  • DCDC3A
• GenBank acession
  • AB002367
• Locus
  13q13.3
• Discovery year
  1999-02-22
• Entrez gene record
  9201
• Pubmed identfication
  • 9747029
  • 10036192
• RefSeq identity
  • NM_004734
• Classification
  • Doublecortin superfamily
• VEGA ID
  OTTHUMG00000016729

Gene info

• Identity
  HGNC:20625
• Gene
  DCDC1
• Long gene name
  doublecortin domain containing 1
• Synonyms gene
  • DCDC5
• Synonyms gene name
  • doublecortin domain containing 5
• Synonyms
  • FLJ46154
• GenBank acession
  • AY247970
• Locus
  11p14.1
• Discovery year
  2003-03-14
• Entrez gene record
  341019
• Pubmed identfication
  • 12820024
• RefSeq identity
  • NM_181807
• Classification
  • Doublecortin superfamily
• VEGA ID
  OTTHUMG00000150144

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products