AZD-6738

Alternative_name

4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine
Description

AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. It also induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines.
CAS Number

1352226-88-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₂₄N₆O₂S
Molecular Weight

412.51
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~0.5 mg/ml)
Handling

Protect from air and light
Tag Line

AZD6738 is an orally active and bioavailable ATR kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

121228639
PubChem CID Link
SMILES

CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4
InChi

InChI=1S/C20H24N6O2S/c1-12-11-28-8-7-26(12)18-10-16(15-9-17(15)29(2,21)27)24-20(25-18)14-4-6-23-19-13(14)3-5-22-19/h3-6,10,12,15,17,21H,7-9,11H2,1-2H3,(H,22,23)/t12-,15?,17-,29-/m1/s1
InChi Key

QCMVAPXCVDFKBD-UYKWCLKASA-N
Data Sheet Link
MSDS Available

Yes