Smo Antagonist, SA9

• Catalog number
  2155-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
• Description
  SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₈ClN₅O₂
• Molecular Weight
  490
• Cell Permeable
  Yes
• Purity
  ≥95% by NMR
• Solubilities
  DMSO
• Handling
  Protect from air and moisture
• Tag Line
  A Hedgehog (Hh) signaling pathway antagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• PubChem CID
  20880974
• PubChem CID Link
• SMILES
  C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
• InChi
  InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
• InChi Key
  YTDIPVZSLXYGNL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  The antagonist receptor ligand binding will be in contrast with agonist activity. Biovision produces more antagonist and receptor related products as 1.

• Gene target
  Smo   Antagonist   SA9  
• Short name
  Smo Antagonist, SA9
• Alternative name
  smoothened, frizzled family receptor Antagonist, SA9
• Alternative to gene target
  smoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308

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