Pexmetinib

• Catalog number
  B1711-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Pexmetinib; ARRY-614; ARRY614; ARRY 614; (Z)-N-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-N'-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)carbamimidic acid; 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]methyl]urea; 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea
• Description
  Pexmetinib (ARRY-614) is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
• CAS Number
  945614-12-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₁H₃₃FN₆O₃
• Molecular Weight
  556.63
• Cell Permeable
  Yes
• Purity
  >98%
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective P38 MAPK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  NA
• PubChem CID
  24765037
• PubChem CID Link
• SMILES
  CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
• InChi
  InChI=1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12,15-17,19,39H,13-14,18H2,1-4H3,(H2,33,35,40)
• InChi Key
  LNMRSSIMGCDUTP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Pexmetinib  
• Short name
  Pexmetinib
• Alternative name
  Pexmetinib

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