Axitinib (AG-013736)
-
Catalog number1581-5
-
PricePlease ask
-
Size5 mg
-
-
Alternative_nameAG-013736
-
DescriptionAxitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117). It has been shown to significantly inhibit growth of breast cancer in xenograft models and renal cell carcinoma (RCC) and several other tumor types.
-
CAS Number319460-85-0
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₂H₁₈N₄OS
-
Molecular Weight386.47
-
Cell PermeableYes
-
Purity≥99% by HPLC
-
SolubilitiesDMSO (10 mM)
-
HandlingProtect from light and moisture
-
Tag LineA PTK inhibitor
-
Storage Condition-20°C
-
Shipping ConditionRT
-
Shelf Life24months
-
MDL NumberMFCD09837898
-
PubChem CID6450551
-
SMILESCNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
-
InChiInChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25- 26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25, 26)/b12-9+
-
InChi KeyRITAVMQDGBJQJZ-FMIVXFBMSA-N
-
MSDS AvailableYes
-
Gene target
-
Gene symbolTPBG, BCAP31
-
Short nameAxitinib (AG-013736)
-
Alternative nameAxitinib (AG-013736)
-
Gene info
-
Identity
-
Gene
-
Long gene nametrophoblast glycoprotein
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1990-10-16
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameB cell receptor associated protein 31
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-12-22
-
Entrez gene record
-
RefSeq identity
-
VEGA ID