Chaetocin

• Catalog number
  2283-500
• Price
  Please ask
• Size
  500 ug

• Alternative_name
  (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)­-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl­)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio­-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4­,4'-tetrone
• Description
  A fungal mycotoxin that inhibits the histone lysine methyltransferase (HKMT) SU(VAR)3-9 (IC₅₀ = 0.8 μM). Inhibits other Lys9-specific HMTs, including G9a (IC₅₀ = 2.5 μM) and DIM5 (IC₅₀ = 3 μM). Selectivity for Lys9-HMTs is indicated by higher IC₅₀ values (>90 μM) for Lys20-specific PRSET7, Lys27-specific EZH2, and Lys4-specific SET7/9.
• CAS Number
  28097-03-2
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₃₀H₂₈N₆O₆S₄
• Molecular Weight
  696.84
• Cell Permeable
  Yes
• Purity
  ≥95%
• Solubilities
  DMSO (~7 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A selective histone lysine methyltransferase (HKMT) inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00133163
• PubChem CID
  161591
• PubChem CID Link
• SMILES
  CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
• InChi
  InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3
• InChi Key
  PZPPOCZWRGNKIR-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Chaetocin  
• Short name
  Chaetocin
• Alternative name
  Chaetocin

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