β-Lapachone

• Catalog number
  2262-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3,4-Dihydro-2,2-dimethyl-2H-naphtho­[1,2-b]pyran-5,6-dione
• Description
  Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin (Cat. No. 1039), β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC₅₀ =3.6 µM).
• CAS Number
  4707-32-8
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₄O₃
• Molecular Weight
  242.27
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (100 mM) or EtOH (50 mM)
• Handling
  Protect from light and mositure
• Tag Line
  A DNA topoisomerase I inhibitor and a histone demethylase (HDM) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD01712233
• PubChem CID
  3885
• PubChem CID Link
• SMILES
  CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C
• InChi
  InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
• InChi Key
  QZPQTZZNNJUOLS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  β-Lapachone  
• Short name
  β-Lapachone
• Alternative name
  β-Lapachone

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