Z-LEHD-FMK

Alternative_name

Z-LEHD-FMK, Z-LEHD-fluoromethylketone, Caspase-9 Inhibitor (fluoromethylketone)
Description

A synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Structure Available

No
Peptide sequence

Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK
Salt Form

No
Molecular Formula

C₃₂H₄₃FN₆O₁₀
Molecular Weight

690.71
Cell Permeable

Yes
Purity

Single spot by TLC
Solubilities

DMSO (20 mM)
Handling

Protect from light and moisture
Tag Line

A caspase-9 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

12 months
MDL Number

MFCD01862609
PubChem CID

44135217
PubChem CID Link
SMILES

CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC (=O)OCC2=CC=CC=C2
InChi

InChI=1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30 (44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23 (26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34, 35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)
InChi Key

YXRKBEPGVHOXSV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042