CO-1686 (Rociletinib)

• Catalog number
  2794-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide; AVL-301
• Description
  CO-1686 is an orally bioavailable, irreversible EGFR inhibitor, selectively targeting EGFRL858R/T790M mutant with a Ki value of 21 nM over Wt EGFR (Ki = 303 nM). Displays potent antineoplastic activities.
• CAS Number
  1374640-70-6
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₈F₃N₇O₃
• Molecular Weight
  555.55
• Cell Permeable
  y
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent EGFR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  57335384
• PubChem CID Link
• SMILES
  CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
• InChi
  InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
• InChi Key
  HUFOZJXAKZVRNJ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CO-1686   Rociletinib  
• Gene symbol
  TSPAN8, AQP1, ENTR1, CWC27, UTP14A, NOXA1, HDAC5, TSHZ1, NEMF, USH1C
• Short name
  CO-1686 (Rociletinib)
• Alternative name
  CO-1686 (Rociletinib)

Gene info

• Identity
  HGNC:11855
• Gene
  TSPAN8
• Long gene name
  tetraspanin 8
• Synonyms gene
  • TM4SF3
• Synonyms gene name
  • transmembrane 4 superfamily member 3
• Synonyms
  • CO-029
• GenBank acession
  • M35252
• Locus
  12q21.1
• Discovery year
  1997-10-16
• Entrez gene record
  7103
• Pubmed identfication
  • 2395876
• RefSeq identity
  • NM_004616
• Classification
  • Tetraspanins
• VEGA ID
  OTTHUMG00000169542

Gene info

• Identity
  HGNC:633
• Gene
  AQP1
• Long gene name
  aquaporin 1 (Colton blood group)
• Synonyms gene
  • CO
• Synonyms gene name
  • Colton blood group
  • aquaporin 1 (channel-forming integral protein, 28kDa)
  • aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group)
  • aquaporin 1
• Synonyms
  • CHIP28
• GenBank acession
  • M77829
• Locus
  7p14.3
• Discovery year
  1993-07-09
• Entrez gene record
  358
• Pubmed identfication
  • 1722319
  • 3166547
• RefSeq identity
  • NM_198098
• Classification
  • Blood group antigens
  • Aquaporins
• VEGA ID
  OTTHUMG00000023944
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_808

Gene info

• Identity
  HGNC:10667
• Gene
  ENTR1
• Long gene name
  endosome associated trafficking regulator 1
• Synonyms gene
  • SDCCAG3
• Synonyms gene name
  • serologically defined colon cancer antigen 3
• Synonyms
  • NY-CO-3
• GenBank acession
  • AF039688
• Locus
  9q34.3
• Discovery year
  1999-08-25
• Entrez gene record
  10807
• Pubmed identfication
  • 9610721
• RefSeq identity
  • NM_006643
• VEGA ID
  OTTHUMG00000020928

Gene info

• Identity
  HGNC:10664
• Gene
  CWC27
• Long gene name
  CWC27 spliceosome associated cyclophilin
• Synonyms gene
  • SDCCAG10
• Synonyms gene name
  • serologically defined colon cancer antigen 10
  • CWC27 spliceosome-associated protein homolog (S. cerevisiae)
  • CWC27 spliceosome-associated protein homolog
  • CWC27 spliceosome associated protein homolog
• Synonyms
  • NY-CO-10
  • SDCCAG-10
• GenBank acession
  • AF039692
• Locus
  5q12.3
• Discovery year
  1999-07-23
• Entrez gene record
  10283
• Pubmed identfication
  • 9610721
  • 19941820
  • 28285769
• RefSeq identity
  • NM_005869
• Classification
  • Cyclophilin peptidylprolyl isomerases
  • Spliceosomal C complex
  • NTC associated proteins
  • Spliceosomal Bact complex
  • Spliceosomal P complex
• VEGA ID
  OTTHUMG00000074069

Gene info

• Identity
  HGNC:10665
• Gene
  UTP14A
• Long gene name
  UTP14A small subunit processome component
• Synonyms gene
  • SDCCAG16
• Synonyms gene name
  • serologically defined colon cancer antigen 16
  • UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
• Synonyms
  • NY-CO-16
  • Utp14
• GenBank acession
  • AF039694
• Locus
  Xq26.1
• Discovery year
  1999-08-25
• Entrez gene record
  10813
• Pubmed identfication
  • 9610721
  • 16354793
  • 21078665
• RefSeq identity
  • NM_006649
• Classification
  • SSU processome
• VEGA ID
  OTTHUMG00000022378

Gene info

• Identity
  HGNC:10668
• Gene
  NOXA1
• Long gene name
  NADPH oxidase activator 1
• Synonyms gene
  • SDCCAG31
• Synonyms gene name
  • serologically defined colon cancer antigen 31
• Synonyms
  • NY-CO-31
  • FLJ25475
• GenBank acession
  • AF039697
• Locus
  9q34.3
• Discovery year
  1999-08-25
• Entrez gene record
  10811
• Pubmed identfication
  • 9610721
• VEGA ID
  OTTHUMG00000131781

Gene info

• Identity
  HGNC:14068
• Gene
  HDAC5
• Long gene name
  histone deacetylase 5
• Synonyms
  • KIAA0600
  • NY-CO-9
  • FLJ90614
• GenBank acession
  • AF249731
• Locus
  17q21.31
• Discovery year
  2000-11-28
• Entrez gene record
  10014
• Pubmed identfication
  • 10220385
  • 9610721
• RefSeq identity
  • NM_001015053
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000181806

Gene info

• Identity
  HGNC:10669
• Gene
  TSHZ1
• Long gene name
  teashirt zinc finger homeobox 1
• Synonyms gene
  • SDCCAG33
• Synonyms gene name
  • serologically defined colon cancer antigen 33
  • teashirt zinc finger 1
  • teashirt family zinc finger 1
• Synonyms
  • NY-CO-33
  • TSH1
• GenBank acession
  • AF039698
• Locus
  18q22.3
• Discovery year
  1999-07-23
• Entrez gene record
  10194
• Pubmed identfication
  • 17586487
• RefSeq identity
  • NM_005786
• Classification
  • ZF class homeoboxes and pseudogenes
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000132859

Gene info

• Identity
  HGNC:10663
• Gene
  NEMF
• Long gene name
  nuclear export mediator factor
• Synonyms gene
  • SDCCAG1
• Synonyms gene name
  • serologically defined colon cancer antigen 1
• Synonyms
  • NY-CO-1
  • FLJ10051
• Synonyms name
  • caliban homolog (Drosophila)
• GenBank acession
  • AF039687
• Locus
  14q21.3
• Discovery year
  1999-02-09
• Entrez gene record
  9147
• Pubmed identfication
  • 9610721
  • 10575219
• RefSeq identity
  • NM_004713
• VEGA ID
  OTTHUMG00000170857

Gene info

• Identity
  HGNC:12597
• Gene
  USH1C
• Long gene name
  USH1 protein network component harmonin
• Synonyms gene
  • DFNB18
• Synonyms gene name
  • deafness, autosomal recessive 18
  • Usher syndrome 1C (autosomal recessive, severe)
  • Usher syndrome 1C
• Synonyms
  • PDZ73
  • harmonin
  • NY-CO-37
  • NY-CO-38
  • PDZ-73
  • AIE-75
  • PDZD7C
• Synonyms name
  • harmonin
• GenBank acession
  • AB006955
• Locus
  11p15.1
• Discovery year
  1992-06-08
• Entrez gene record
  10083
• Pubmed identfication
  • 10973247
  • 12107438
• RefSeq identity
  • NM_005709
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000166323
• Locus Specific Databases
  • Mutations of the Harmonin Gene
  • CCHMC-BMI & UC Hearing Loss Mutation Database

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