Recombinant Human Neuroligin 1 / NLGN1 Protein (His tag) 100µg

• Catalog number
  PKSH031062-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  NL1
• Activity
  NA
• Sequence
  Met 1-Ser 677
• Fusion tag
  C-His
• Accession
  NP_055747.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  72 kDa
• AP Mol Mass
  85-95 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consist of five members (NLGN1, NLGN2, NLGN3, NLGN4 and NLGN4Y), which interact with beta-neurexins and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Neuroligin   NLGN1   Protein   His   tag   100µg  
• Gene symbol
  NLGN1, NLGN1-AS1
• Short name
  Recombinant Neuroligin 1 / NLGN1 Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Neuroligin 1 / neuroligin 1 Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  neuroligin 1, NL1, NLGN1 and IDBG-65853 and ENSG00000169760 and 22871, cell adhesion molecule binding, Cell surfaces, Nlgn1 and IDBG-133960 and ENSMUSG00000063887 and 192167, NLGN1 and IDBG-636117 and ENSBTAG00000031891 and 530042

Gene info

• Identity
  HGNC:14291
• Gene
  NLGN1
• Long gene name
  neuroligin 1
• Synonyms
  • KIAA1070
• GenBank acession
  • AB028993
• Locus
  3q26.31
• Discovery year
  2001-01-02
• Entrez gene record
  22871
• Pubmed identfication
  • 10767552
  • 10819331
• RefSeq identity
  • NM_014932
• Classification
  • Neuroligins
• VEGA ID
  OTTHUMG00000157005

Gene info

• Identity
  HGNC:40676
• Gene
  NLGN1-AS1
• Long gene name
  NLGN1 antisense RNA 1
• Synonyms gene name
  • NLGN1 antisense RNA 1 (non-protein coding)
• Locus
  3q26.31
• Discovery year
  2011-07-27
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000157016

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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