YK-4-279

• Catalog number
  2846-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
• Description
  YK-4-279 is an Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC₅₀ values ranging from 0.5-2 µM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
• CAS Number
  1037184-44-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₇H₁₃Cl₂NO₄
• Molecular Weight
  366.2
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44632017
• PubChem CID Link
• SMILES
  COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O
• InChi
  InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22)
• InChi Key
  HLXSCTYHLQHQDJ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  YK-4-279  
• Gene symbol
  CHI3L1, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4, IGKV2OR2-4, ANKRD20A12P
• Short name
  YK-4-279
• Alternative name
  YK-4-279

Gene info

• Identity
  HGNC:1932
• Gene
  CHI3L1
• Long gene name
  chitinase 3 like 1
• Synonyms gene name
  • chitinase 3-like 1 (cartilage glycoprotein-39)
• Synonyms
  • GP39
  • YKL40
  • YK-40
• Synonyms name
  • cartilage glycoprotein-39
• GenBank acession
  • BC008568
• Locus
  1q32.1
• Discovery year
  1994-12-20
• Entrez gene record
  1116
• Pubmed identfication
  • 8245017
  • 9244440
• RefSeq identity
  • NM_001276
• Classification
  • Chitinases
• VEGA ID
  OTTHUMG00000042122

Gene info

• Identity
  HGNC:35296
• Gene
  MIR1302-4
• Long gene name
  microRNA 1302-4
• Synonyms gene
  • MIRN1302-4
• Synonyms
  • hsa-mir-1302-4
• Locus
  2q33.3
• Discovery year
  2008-11-03
• Entrez gene record
  100302130
• RefSeq identity
  • NR_031633
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37522
• Gene
  PIRC18
• Long gene name
  piwi-interacting RNA cluster 18
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313906
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37520
• Gene
  PIRC16
• Long gene name
  piwi-interacting RNA cluster 16
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313849
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32992
• Gene
  SNORD114-4
• Long gene name
  small nucleolar RNA, C/D box 114-4
• Synonyms
  • 14q(II-4)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767580
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003196.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33687
• Gene
  MIR941-4
• Long gene name
  microRNA 941-4
• Synonyms gene
  • MIRN941-4
• Synonyms
  • hsa-mir-941-4
• Locus
  20q13.33
• Discovery year
  2007-10-24
• Entrez gene record
  100126330
• RefSeq identity
  • NR_040032
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:5809
• Gene
  IGKV2OR2-4
• Long gene name
  immunoglobulin kappa variable 2/OR2-4 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2/OR2-4
  • immunoglobulin kappa variable 2/OR2-4 pseudogene
• Synonyms
  • IGKV2/OR2-4
• GenBank acession
  • X51883
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28858
• Pubmed identfication
  • 2111145
• Classification
  • Immunoglobulin kappa (IGK) orphons

Gene info

• Identity
  HGNC:43603
• Gene
  ANKRD20A12P
• Long gene name
  ankyrin repeat domain 20 family member A12, pseudogene
• Synonyms gene name
  • ankyrin repeat domain 20 family, member A12, pseudogene
• Locus
  4
• Discovery year
  2011-11-23
• Entrez gene record
  100874392

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