JNJ-26854165

• Catalog number
  2479-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine; Serdemetan
• Description
  A novel p53-activating tryptamine derivative that acts as a HDM2 (Human Double Minute-2) antagonist with potential antineoplastic activity. JNJ-26854165 inhibits the binding of the HDM2–p53 complex to the proteasome, blocking the degradation of p53. It displays potent anti-proliferative and apoptosis-inducing activity in a broad range of p53 wild type and mutant tumor models.
• CAS Number
  881202-45-5
• Structure Available
  Yes
• Molecular Formula
  C₂₁H₂₀N₄
• Molecular Weight
  328.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A novel HDM2 (Human Double Minute-2) antagonist
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  11609586
• PubChem CID Link
• SMILES
  C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
• InChi
  InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
• InChi Key
  CEGSUKYESLWKJP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  JNJ-26854165  
• Short name
  JNJ-26854165
• Alternative name
  JNJ-26854165

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