Recombinant Mouse CD59a / Protectin / MAC-IP Protein (His tag) 50µg

• Catalog number
  PKSM040521-50µg
• Price
  Please ask
• Size
  50µg

• Activity
  NA
• Synonym
  AA987121;Cd59;protectin;RP24-297H17.1
• Sequence
  Met 1-Lys 95
• Fusion tag
  C-His
• Accession
  NP_031680.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 92 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  9.7 kDa
• AP Mol Mass
  18 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD59a   Protectin   MAC-IP   Protein   His   tag   50µg  
• Gene symbol
  PTGIR, LGALS3, TSACC, ITGAM, ITGB2, ATP5IF1, IFI30, LGALS3BP, CXCL11, CXCL10
• Short name
  Recombinant Mouse CD59a / Protectin / MAC-IP Protein (His tag) 50µg
• Technique
  Recombinant, Mouse, IP, Immunoprecipitation, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse CD59a / Protectin / MAC-IP Protein (histidine detection labelled) 50µg
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:9602
• Gene
  PTGIR
• Long gene name
  prostaglandin I2 receptor
• Synonyms gene name
  • prostaglandin I2 (prostacyclin) receptor (IP)
• Synonyms
  • IP
• Synonyms name
  • prostacyclin receptor
• Locus
  19q13.32
• Discovery year
  1994-07-29
• Entrez gene record
  5739
• Pubmed identfication
  • 7759114
• Classification
  • Prostaglandin receptors
• VEGA ID
  OTTHUMG00000183429

Gene info

• Identity
  HGNC:6563
• Gene
  LGALS3
• Long gene name
  galectin 3
• Synonyms gene
  • LGALS2
• Synonyms gene name
  • lectin, galactoside-binding, soluble, 3
• Synonyms
  • MAC-2
  • GALIG
• Synonyms name
  • advanced glycation end-product receptor 3
• GenBank acession
  • M64303
• Locus
  14q22.3
• Discovery year
  1991-09-13
• Entrez gene record
  3958
• Pubmed identfication
  • 2009535
  • 8063692
• RefSeq identity
  • NM_002306
• Classification
  • Receptor ligands
  • Galectins
• VEGA ID
  OTTHUMG00000171030

Gene info

• Identity
  HGNC:30636
• Gene
  TSACC
• Long gene name
  TSSK6 activating cochaperone
• Synonyms gene
  • C1orf182
• Synonyms gene name
  • chromosome 1 open reading frame 182
• Synonyms
  • SSTK-IP
  • SIP
• Synonyms name
  • SSTK-interacting protein
• GenBank acession
  • AY048672
• Locus
  1q22
• Discovery year
  2005-08-01
• Entrez gene record
  128229
• Pubmed identfication
  • 20829357
• RefSeq identity
  • NM_144627
• VEGA ID
  OTTHUMG00000024060

Gene info

• Identity
  HGNC:6149
• Gene
  ITGAM
• Long gene name
  integrin subunit alpha M
• Synonyms gene
  • CR3A
  • CD11B
• Synonyms gene name
  • integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)
  • integrin, alpha M (complement component 3 receptor 3 subunit)
• Synonyms
  • MAC-1
  • CD11b
• Synonyms name
  • complement component 3 receptor 3 subunit
  • macrophage-1 antigen alpha subunit
• GenBank acession
  • J03925
• Locus
  16p11.2
• Discovery year
  1988-08-05
• Entrez gene record
  3684
• RefSeq identity
  • NM_000632
• Classification
  • Integrin alpha subunits
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000176612
• Locus Specific Databases
  • LRG_1333

Gene info

• Identity
  HGNC:6155
• Gene
  ITGB2
• Long gene name
  integrin subunit beta 2
• Synonyms gene
  • CD18
  • MFI7
• Synonyms gene name
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
• Synonyms
  • LFA-1
  • MAC-1
• Synonyms name
  • complement component 3 receptor 3 and 4 subunit
• GenBank acession
  • AK222505
• Locus
  21q22.3
• Discovery year
  1986-01-01
• Entrez gene record
  3689
• RefSeq identity
  • NM_000211
• Classification
  • Integrin beta subunits
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000090257
• Locus Specific Databases
  • ITGB2base: Mutation registry for Leukocyte adhesion deficiency I (LAD-I)
  • LRG_76

Gene info

• Identity
  HGNC:871
• Gene
  ATP5IF1
• Long gene name
  ATP synthase inhibitory factor subunit 1
• Synonyms gene
  • ATPIF1
• Synonyms gene name
  • ATPase inhibitory factor 1
• Synonyms
  • ATPI
  • IP
  • ATPIP
  • MGC1167
  • MGC8898
• Synonyms name
  • ATPase inhibitor protein
  • ATP synthase inhibitor protein
• GenBank acession
  • AL050386
• Locus
  1p35.3
• Discovery year
  2000-02-29
• Entrez gene record
  93974
• Pubmed identfication
  • 10664857
  • 19559621
• RefSeq identity
  • NM_016311
• Classification
  • Mitochondrial complex V: ATP synthase subunits
• VEGA ID
  OTTHUMG00000003533

Gene info

• Identity
  HGNC:5398
• Gene
  IFI30
• Long gene name
  IFI30 lysosomal thiol reductase
• Synonyms gene name
  • interferon gamma inducible protein 30
  • IFI30, lysosomal thiol reductase
• Synonyms
  • IFI-30
  • GILT
  • IP30
  • MGC32056
  • IP-30
• Synonyms name
  • gamma-interferon-inducible lysosomal thiol reductase
  • interferon gamma-inducible protein 30 preproprotein
  • legumaturain
• GenBank acession
  • J03909
• Locus
  19p13.11
• Discovery year
  1999-12-09
• Entrez gene record
  10437
• Pubmed identfication
  • 3136170
  • 10639150
• RefSeq identity
  • NM_006332
• VEGA ID
  OTTHUMG00000183373

Gene info

• Identity
  HGNC:6564
• Gene
  LGALS3BP
• Long gene name
  galectin 3 binding protein
• Synonyms gene name
  • lectin, galactoside-binding, soluble, 3 binding protein
• Synonyms
  • MAC-2-BP
  • 90K
  • BTBD17B
  • TANGO10B
  • M2BP
  • gp90
  • CyCAP
• Synonyms name
  • L3 antigen
  • Mac-2-binding protein
  • serum protein 90K
  • transport and golgi organization 10 homolog B (Drosophila)
• GenBank acession
  • L13210
• Locus
  17q25
• Discovery year
  1994-09-30
• Entrez gene record
  3959
• Pubmed identfication
  • 7698018
  • 8034587
  • 8390986
• RefSeq identity
  • NM_005567
• Classification
  • BTB domain containing
  • Scavenger receptor cysteine rich domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000177572

Gene info

• Identity
  HGNC:10638
• Gene
  CXCL11
• Long gene name
  C-X-C motif chemokine ligand 11
• Synonyms gene
  • SCYB9B
  • SCYB11
• Synonyms gene name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 11
  • chemokine (C-X-C motif) ligand 11
• Synonyms
  • H174
  • b-R1
  • I-TAC
  • IP-9
• GenBank acession
  • U66096
• Locus
  4q21.1
• Discovery year
  1998-06-23
• Entrez gene record
  6373
• Pubmed identfication
  • 9730616
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130101

Gene info

• Identity
  HGNC:10637
• Gene
  CXCL10
• Long gene name
  C-X-C motif chemokine ligand 10
• Synonyms gene
  • INP10
  • SCYB10
• Synonyms gene name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 10
  • chemokine (C-X-C motif) ligand 10
• Synonyms
  • IFI10
  • IP-10
  • crg-2
  • mob-1
  • C7
  • gIP-10
• GenBank acession
  • X02530
• Locus
  4q21.1
• Discovery year
  1999-12-09
• Entrez gene record
  3627
• Pubmed identfication
  • 2437586
  • 3925348
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000160887

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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