HDAC3/HD3 Antibody, ALEXA FLUOR 555

• Catalog number
  bs-10024R-A555
• Price
  Please ask
• Size
  100ul

• Long name
  HDAC3/HD3 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
• Also known as
  Anti-HDAC3/HD3 PAb ALEXA FLUOR 555
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 555
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  HDAC3/HD3
• Specificity
  This is a highly specific antibody against HDAC3/HD3.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC3/HD3
• Gene ID Number
  8841
• Swiss Prot
  O15379
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  553nm/568nm
• Synonyms
  HD3; RPD3; RPD3-2; Histone deacetylase 3; SMAP45; HDAC3
• Properties
  For facs or microscopy Alexa 1 conjugate. Very high photo stable ALEXA conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 555
• French translation
  anticorps

• Gene target
  HDAC3/HD3  
• Gene symbol
  HDAC3
• Short name
  Anti-HDAC3/HD3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 555
• Alternative name
  HDAC3/HD3 Polyclonal Antibody, ALEXA FLUOR 555
• Alternative technique
  antibodies
• Alternative to gene target
  histone deacetylase 3, HD3 and RPD3 and RPD3-2, HDAC3 and IDBG-50725 and ENSG00000171720 and 8841, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, Hdac3 and IDBG-140814 and ENSMUSG00000024454 and 15183, HDAC3 and IDBG-646121 and ENSBTAG00000017360 and 404125

Gene info

• Identity
  HGNC:4854
• Gene
  HDAC3
• Long gene name
  histone deacetylase 3
• Synonyms
  • RPD3
  • HD3
  • RPD3-2
  • KDAC3
• GenBank acession
  • AF059650
• Locus
  5q31.3
• Discovery year
  1999-01-29
• Entrez gene record
  8841
• Pubmed identfication
  • 9501169
  • 9464271
• RefSeq identity
  • NM_003883
• Classification
  • NCoR/SMRT transcriptional repression complex subunits
  • Histone deacetylases, class I
• VEGA ID
  OTTHUMG00000129629

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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