KM-11060

Alternative_name

7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Description

KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 (phosphodiesterase type 5) activity.
CAS Number

774549-97-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₁₇Cl₂N₃O₂S
Molecular Weight

422.33
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A cystic fibrosis transmembrane conductance regulator (CFTR) corrector
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

1241327
PubChem CID Link
SMILES

C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl
InChi

InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
InChi Key

GIEHIZKCIZLXLF-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes