PYR-41

Alternative_name

4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Description

Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
CAS Number

418805-02-4
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₇H₁₃N₃O₇
Molecular Weight

371.3
Cell Permeable

Yes
Purity

≥98% by TLC
Solubilities

DMSO (~25 mg/ml)
Handling

Protect from light and air
Tag Line

An irreversible ubiquitin-activating enzyme (E1) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

5335621
PubChem CID Link
SMILES

CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
InChi

InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChi Key

ARGIPZKQJGFSGQ-LCYFTJDESA-N
Data Sheet Link
MSDS Available

Yes

Gene target

PYR-41
Gene symbol

SNORD115-41, IGHV3-41, IGLVVII-41-1, IGKV6D-41, IGLV1-41, CCDC18, RNU6-41P, TRIM71, METTL25B, CCDC34
Short name

PYR-41
Alternative name

PYR-41

Identity

HGNC:5602
Gene

IGHV3-41
Long gene name

immunoglobulin heavy variable 3-41 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable 3-41
- immunoglobulin heavy variable 3-41 pseudogene
GenBank acession
- M99670
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28428
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152089

Identity

HGNC:15691
Gene

IGLVVII-41-1
Long gene name

immunoglobulin lambda variable (VII)-41-1 (pseudogene)
Synonyms gene name
- immunoglobulin lambda variable (VII)-41-1
- immunoglobulin lambda variable (VII)-41-1 pseudogene
Synonyms
- IGLV(VII)-41-1
GenBank acession
- X99568
Locus

22q11.22
Discovery year

2001-05-15
Entrez gene record

84089
RefSeq identity
- NG_000002
Classification
- Immunoglobulin lambda locus at 22q11.2
VEGA ID

OTTHUMG00000151296

Identity

HGNC:5878
Gene

IGLV1-41
Long gene name

immunoglobulin lambda variable 1-41 (pseudogene)
Synonyms gene name
- immunoglobulin lambda variable 1-41
- immunoglobulin lambda variable 1-41 pseudogene
GenBank acession
- M94118
Locus

22q11.22
Discovery year

2000-05-08
Entrez gene record

28824
RefSeq identity
- NG_000002
Classification
- Immunoglobulin lambda locus at 22q11.2
VEGA ID

OTTHUMG00000151056

Identity

HGNC:32669
Gene

TRIM71
Long gene name

tripartite motif containing 71
Synonyms gene name
- tripartite motif containing 71, E3 ubiquitin protein ligase
Synonyms
- LIN41
- LIN-41
Locus

3p22.3
Discovery year

2006-03-30
Entrez gene record

131405
RefSeq identity
- NM_001039111
Classification
- Ring finger proteins
- Tripartite motif containing
VEGA ID

OTTHUMG00000155778

Identity

HGNC:24273
Gene

METTL25B
Long gene name

methyltransferase like 25B
Synonyms gene
- C1orf66
- RRNAD1
Synonyms gene name
- chromosome 1 open reading frame 66
- ribosomal RNA adenine dimethylase domain containing 1
Synonyms
- CGI-41
GenBank acession
- BC011382
Locus

1q23.1
Discovery year

2005-05-17
Entrez gene record

51093
Pubmed identfication
- 10810093
- 310876
RefSeq identity
- NM_015997
Classification
- 7BS orphan methyltransferases
VEGA ID

OTTHUMG00000041302