Nampt-IN-1

Alternative_name

2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
Description

Nampt-IN-1 is a potent and selective NAMPT (Nicotinamide phosphoribosyltransferase) inhibitor. Displays potent anticancer properties. NAMPT is found to be upregulated in various cancer cells and inhibition of NAMPT leads to depletion of NAD+ which leads to low levels of ATP resulting in attenuation of proliferating cancer cells.
CAS Number

1698878-14-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₂₅N₃O₅S
Molecular Weight

419.49
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent and selective NAMPT (Nicotinamide phosphoribosyltransferase) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

92044379
PubChem CID Link
SMILES

CC(C)(CS(=O)(=O)NC1=CC2=C(CN(CC2)C(=O)COC3=CN=CC=C3)C=C1)O
InChi

InChI=1S/C20H25N3O5S/c1-20(2,25)14-29(26,27)22-17-6-5-16-12-23(9-7-15(16)10-17)19(24)13-28-18-4-3-8-21-11-18/h3-6,8,10-11,22,25H,7,9,12-14H2,1-2H3
InChi Key

QHHSCLARESIWBH-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

Nampt-IN-1
Gene symbol

CD44, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1
Short name

Nampt-IN-1
Alternative name

nicotinamide phosphoribosyltransferase-IN-1
Alternative to gene target

nicotinamide phosphoribosyltransferase, 1110035O14Rik and PBEF and PBEF1 and VF and VISFATIN, NAMPT and IDBG-35259 and ENSG00000105835 and 10135, nicotinamide phosphoribosyltransferase activity, nuclei, Nampt and IDBG-134049 and ENSMUSG00000020572 and 59027, BT.33608 and IDBG-632034 and ENSBTAG00000015509 and 520472

Identity

HGNC:1681
Gene

CD44
Long gene name

CD44 molecule (Indian blood group)
Synonyms gene
- MIC4
- MDU2
- MDU3
Synonyms gene name
- CD44 antigen (homing function and Indian blood group system)
Synonyms
- IN
- MC56
- Pgp1
- CD44R
- HCELL
- CSPG8
Synonyms name
- hematopoietic cell E- and L-selectin ligand
- chondroitin sulfate proteoglycan 8
GenBank acession
- M59040
Locus

11p13
Discovery year

1989-06-30
Entrez gene record

960
Pubmed identfication
- 2454887
RefSeq identity
- NM_000610
Classification
- Proteoglycans
- Blood group antigens
- CD molecules
VEGA ID

OTTHUMG00000044388
Locus Specific Databases
- LRG_815

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081