FLI-06

• Catalog number
  2603-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
• Description
  A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.
• CAS Number
  313967-18-9
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₅H₃₀N₂O₅
• Molecular Weight
  438.52
• Cell Permeable
  Yes
• Purity
  >98% by HPLC
• Solubilities
  DMSO (~40 mg/ml) or EtOH (~ 8 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent Notch signaling inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  3103157
• PubChem CID Link
• SMILES
  CC1(C)CC(C(C(C2=CC=C([N+]([O-])=O)C=C2)C(C(OC3CCCCC3)=O)=C(C)N4)=C4C1)=O
• InChi
  InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
• InChi Key
  SWWVFYHSSOWZMF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  FLI-06  
• Gene symbol
  FLII, ITPA, HCG4B
• Short name
  FLI-06
• Alternative name
  FLI-06

Gene info

• Identity
  HGNC:3750
• Gene
  FLII
• Long gene name
  FLII actin remodeling protein
• Synonyms gene name
  • flightless I (Drosophila) homolog
  • flightless I homolog (Drosophila)
  • flightless I actin binding protein
• Synonyms
  • FLI
  • FLIL
  • Fli1
  • MGC39265
• GenBank acession
  • U01184
• Locus
  17p11.2
• Discovery year
  1995-10-11
• Entrez gene record
  2314
• Pubmed identfication
  • 7825574
  • 26521845
  • 22581781
• RefSeq identity
  • NM_002018
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000059389

Gene info

• Identity
  HGNC:6176
• Gene
  ITPA
• Long gene name
  inosine triphosphatase
• Synonyms gene
  • C20orf37
• Synonyms gene name
  • inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
• Synonyms
  • HLC14-06-P
  • dJ794I6.3
• Synonyms name
  • nucleoside-triphosphate diphosphatase
• GenBank acession
  • AF026816
• Locus
  20p13
• Discovery year
  1986-01-01
• Entrez gene record
  3704
• Pubmed identfication
  • 11278832
• RefSeq identity
  • NM_033453
• VEGA ID
  OTTHUMG00000031738

Gene info

• Identity
  HGNC:22919
• Gene
  HCG4B
• Long gene name
  HLA complex group 4B
• Synonyms gene
  • HCG4P6
• Synonyms gene name
  • HLA complex group 4 pseudogene 6
  • HLA complex group 4B (non-protein coding)
• Synonyms
  • HCGIV-6
  • HCGIV.5
  • HCGIV-06
  • bCX67J3.3
  • Em:AB023056.16
  • bPG309N1.1
  • bQB90C11.3
• Synonyms name
  • HCGIV-6 pseudogene
• GenBank acession
  • X81005
• Locus
  6p22.1
• Discovery year
  2003-09-01
• Entrez gene record
  80868
• Pubmed identfication
  • 10557312
• RefSeq identity
  • NR_001317
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000031188

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