anti- DDB1 antibody

• Catalog number
  FNab02284
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
• Immunogen
  damage-specific DNA binding protein 1, 127kDa
• Synonyms
  XAP1
• Calculated MW
  135 kDa
• Uniprot ID
  Q16531
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
• Image1
  Immunohistochemistry of paraffin-embedded human colon cancer using FNab02284(DDB1 antibody) at dilution of 1:50
• Image4
  mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab02284(DDB1 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DDB1  
• Gene symbol
  DDB1
• Short name
  anti- DDB1 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- DDB1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2717
• Gene
  DDB1
• Long gene name
  damage specific DNA binding protein 1
• Synonyms gene name
  • damage-specific DNA binding protein 1 (127kD)
• GenBank acession
  • AJ002955
• Locus
  11q12.2
• Discovery year
  1995-07-06
• Entrez gene record
  1642
• Pubmed identfication
  • 8530102
  • 10574459
• RefSeq identity
  • NM_001923
• Classification
  • Nucleotide excision repair
• VEGA ID
  OTTHUMG00000168209
• Locus Specific Databases
  • LRG_474

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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