Nutlin-3b

• Catalog number
  B1227-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
• Description
  Nutlin-3b is less potent (+)-enantiomer of Nutlin-3 as p53 MDM2 inhibitor in comparison with more potent opposite (-)-enantiomer Nutlin-3a. Nutlin-3b may be used as negative control for non-MDM2 cellular activities. Potency of Nutlin-3b is much lower in the wild type p53 cells and has no effect regardless of the status of p53 cells.
• CAS Number
  675576-97-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₃₀Cl₂N₄O₄
• Molecular Weight
  581.49
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>14 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A useful negative control for for non-MDM2 cellular activities
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  16755649
• PubChem CID Link
• SMILES
  CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
• InChi
  InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
• InChi Key
  BDUHCSBCVGXTJM-IZLXSDGUSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Nutlin-3b  
• Short name
  Nutlin-3b
• Alternative name
  Nutlin-3b

Similar products