JAK Inhibitor, Pyridone 6

• Catalog number
  2534-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  2-​(1,​1-​Dimethylethyl)-​9-​fluoro-​1,​6-​dihydro-​7H-​benz[h]imidazo[4,​5-​f]isoquinolin-​7-​one; Pyridone 6; CMP 6
• Description
  Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.
• CAS Number
  457081-03-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₆FN₃O
• Molecular Weight
  309.3
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  DMSO (5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent JAK inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD17019334
• PubChem CID
  5494425
• PubChem CID Link
• SMILES
  CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
• InChi
  InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
• InChi Key
  VNDWQCSOSCCWIP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  JAK   Inhibitor   Pyridone  
• Gene symbol
  JAK3
• Short name
  JAK Inhibitor, Pyridone 6
• Alternative name
  JAK suppressor, Pyridone 6

Gene info

• Identity
  HGNC:6193
• Gene
  JAK3
• Long gene name
  Janus kinase 3
• Synonyms
  • L-JAK
  • JAKL
  • LJAK
  • JAK3_HUMAN
  • JAK-3
• Synonyms name
  • tyrosine-protein kinase JAK3
  • leukocyte Janus kinase
• GenBank acession
  • U31601
• Locus
  19p13.11
• Discovery year
  1994-12-19
• Entrez gene record
  3718
• Pubmed identfication
  • 8921370
  • 9226382
• RefSeq identity
  • NM_000215
• Classification
  • Jak family tyrosine kinases
• VEGA ID
  OTTHUMG00000165648
• Locus Specific Databases
  • JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency
  • LRG_77

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