VX-765

Alternative_name

(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide; Belnacasan
Description

VX-765 is a prodrug of VRT-043198, a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 displays 100- to 10,000-fold selectivity against caspase-3 and -6 to -9. Exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18.
CAS Number

273404-37-8
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₄H₃₃ClN₄O₆
Molecular Weight

508.99
Cell Permeable

Y
Purity

≥98% by HPLC
Solubilities

DMSO (~ 200 mg/ml)
Handling

Protect from air and light
Tag Line

A selective caspase-1 inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

11398092
PubChem CID Link
SMILES

CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
InChi

InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1
InChi Key

SJDDOCKBXFJEJB-MOKWFATOSA-N
Data Sheet Link
MSDS Available

Yes