ITE

• Catalog number
  B1579-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester; Aryl hydrocarbon receptor ligand
• Description
  ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Mechanically, ITE bound AhR inhibits transcription of OCT4, an inducer of pluripotent stem cells, through direct binding to OCT4 promoter. As a consequence, ITE treatment significantly represses the tumor formation in xenograft model using injection of U87 cells.
• CAS Number
  448906-42-1
• Structure Available
  Yes
• Molecular Formula
  C₁₄H₁₀N₂O₃S
• Molecular Weight
  286.3
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An endogenous aryl hydrocarbon receptor (AhR) agonist
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  4668801
• PubChem CID Link
• SMILES
  COC(=O)C1=CSC(=N1)C(=O)C2=CNC3=CC=CC=C32
• InChi
  InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3
• InChi Key
  KDDXOGDIPZSCTM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ITE  
• Short name
  ITE
• Alternative name
  ITE

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