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Alternative_name
(5-Amino-1H-1,2,4-triazol-3-yl)thio]acetic acid (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester,14-O-(5-(2-Amino1,3,4-triazolyl)thioacetyl)dihydromutilin, Antibiotic TDM 85-530
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Description
Azamulin is a derivative of the antibiotic pleuromutilin. It is a highly selective inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM as reported in Stresser et al., DMD, January 2004 vol. 32 no. 1 p105-112). Azamulin is a 15 and 13 fold more potent inhibitor of CYP3A4 compared to CYP3A5 or CYP3A7 respectively making it very useful for CYP3A4 activity assays and can be used as a benchmark in CYP3A4 inhibitor screening assays. It is at least 100 fold selective over other CYP isoforms (except CYP2J2 ~ 50-fold).
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CAS Number
76530-44-4
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₄H₃₈N₄O₄S
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Molecular Weight
478.65
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~10 mg/ml), Acetonitrile (~4.8 mg/ml)
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Handling
Protect from air, light and moisture
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Tag Line
A potent and specific inhibitor of CYP3A4
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD00865055
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PubChem CID
3086060
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SMILES
CCC1(CC(C2(C(CCC3(C2C(=O)CC3)C(C1O)C)C)C)OC(=O)CSC4=NNC(=N4)N)C
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InChi
InChI=1S/C24H38N4O4S/c1-6-22(4)11-16(32-17(30)12-33-21-26-20(25)27-28-21)23(5)13(2)7-9-24(14(3)19(22)31)10-8-15(29)18(23)24/h13-14,16,18-19,31H,6-12H2,1-5H3,(H3,25,26,27,28)/t13?,14-,16+,18-,19-,22+,23-,24-/m0/s1
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InChi Key
FMHQJXGMLMSMLC-GUNZQCIYSA-N
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MSDS Available
Yes
