KN-62

• Catalog number
  2495-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  4-​[(2S)-​2-​[(5-​isoquinolinylsulfonyl)methylamino]-​3-​oxo-​3-​(4-​phenyl-​1-​piperazinyl)propyl]phenyl ester,​ 5-​isoquinolinesulfonic acid
• Description
  Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC₅₀ = 15 nM).
• CAS Number
  127191-97-3
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₃₈H₃₅N₅O₆S₂
• Molecular Weight
  721.84
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00083180
• PubChem CID
  5312126
• PubChem CID Link
• SMILES
  CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
• InChi
  InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
• InChi Key
  RJVLFQBBRSMWHX-DHUJRADRSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  KN-62  
• Gene symbol
  CR1, IGLV1-62, IGHV3-62, IGHVII-62-1, RNU6-62P, ZC2HC1A, KIF15, SNW1
• Short name
  KN-62
• Alternative name
  KN-62

Gene info

• Identity
  HGNC:2334
• Gene
  CR1
• Long gene name
  complement C3b/C4b receptor 1 (Knops blood group)
• Synonyms gene name
  • complement component (3b/4b) receptor 1, including Knops blood group system
  • complement component (3b/4b) receptor 1 (Knops blood group)
  • complement component 3b/4b receptor 1 (Knops blood group)
• Synonyms
  • CD35
  • KN
• GenBank acession
  • Y00816
• Locus
  1q32.2
• Discovery year
  2001-06-22
• Entrez gene record
  1378
• Pubmed identfication
  • 1708809
• RefSeq identity
  • NM_000573
• Classification
  • Blood group antigens
  • Complement system regulators and receptors
  • CD molecules
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000036311
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_814

Gene info

• Identity
  HGNC:5883
• Gene
  IGLV1-62
• Long gene name
  immunoglobulin lambda variable 1-62 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 1-62
  • immunoglobulin lambda variable 1-62 pseudogene
• GenBank acession
  • D87022
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28819
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000150848

Gene info

• Identity
  HGNC:5615
• Gene
  IGHV3-62
• Long gene name
  immunoglobulin heavy variable 3-62 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-62
  • immunoglobulin heavy variable 3-62 pseudogene
• GenBank acession
  • M29814
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28416
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151950

Gene info

• Identity
  HGNC:5687
• Gene
  IGHVII-62-1
• Long gene name
  immunoglobulin heavy variable (II)-62-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-62-1
  • immunoglobulin heavy variable (II)-62-1 pseudogene
• Synonyms
  • IGHV(II)-62-1
• GenBank acession
  • AB019437
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28360
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151965

Gene info

• Identity
  HGNC:42552
• Gene
  RNU6-62P
• Long gene name
  RNA, U6 small nuclear 62, pseudogene
• Synonyms gene
  • RNU6-62
• Synonyms gene name
  • RNA, U6 small nuclear 62
• Locus
  13q32.1
• Discovery year
  2011-08-08
• Entrez gene record
  106478987

Gene info

• Identity
  HGNC:24277
• Gene
  ZC2HC1A
• Long gene name
  zinc finger C2HC-type containing 1A
• Synonyms gene
  • C8orf70
  • FAM164A
• Synonyms gene name
  • chromosome 8 open reading frame 70
  • family with sequence similarity 164, member A
• Synonyms
  • CGI-62
• Locus
  8q21.13
• Discovery year
  2005-09-22
• Entrez gene record
  51101
• Pubmed identfication
  • 10810093
• RefSeq identity
  • NM_016010
• Classification
  • Zinc fingers C2HC-type
• VEGA ID
  OTTHUMG00000164619

Gene info

• Identity
  HGNC:17273
• Gene
  KIF15
• Long gene name
  kinesin family member 15
• Synonyms gene
  • KNSL7
• Synonyms gene name
  • kinesin-like 7
• Synonyms
  • HKLP2
  • NY-BR-62
• GenBank acession
  • AB035898
• Locus
  3p21.31
• Discovery year
  2001-12-11
• Entrez gene record
  56992
• Pubmed identfication
  • 10878014
• Classification
  • Kinesins
• VEGA ID
  OTTHUMG00000156307

Gene info

• Identity
  HGNC:16696
• Gene
  SNW1
• Long gene name
  SNW domain containing 1
• Synonyms gene
  • SKIIP
• Synonyms gene name
  • SKI interacting protein
• Synonyms
  • NCoA-62
  • SKIP
  • Prp45
  • PRPF45
  • Bx42
  • SKIP1
  • FUN20
• GenBank acession
  • AF045184
• Locus
  14q24.3
• Discovery year
  2004-05-25
• Entrez gene record
  22938
• Pubmed identfication
  • 8973337
  • 9632709
• RefSeq identity
  • NM_012245
• Classification
  • NTC associated proteins
  • Spliceosomal B complex
  • Spliceosomal Bact complex
  • Spliceosomal P complex
  • Spliceosomal C complex
• VEGA ID
  OTTHUMG00000171527

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