HDAC1/2 (Ser423/424) Antibody, ALEXA FLUOR 594

• Catalog number
  bs-5387R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  HDAC1/2 (Ser423/424) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-HDAC1/2 Ser423/424 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  HDAC1/2 Ser423/424
• Specificity
  This is a highly specific antibody against HDAC1/2 Ser423/424.
• Modification
  Phosphorylation
• Modification Site
  Ser423/424
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human HDAC1 around phosphorylation site of Ser423
• Gene ID Number
  3065
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  HD 1 Phospho Ser423; HD1; HDAC 1 Phospho Ser423; histone deacetylase 1 Phospho Ser423; Histone deacetylase 1 HD1 Phospho Ser423; Histone deacetylase 1; RPD3 reduced potassium dependency yeast homolog like 1; RPD3 reduced potassium dependency; RPD3; RPD3L1; HDAC2_HUMAN. HDAC2 Phospho Ser424; Histone deacetylase 2 Phospho Ser424.
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  HDAC1/2   Ser423/424  
• Gene symbol
  HDAC1
• Short name
  Anti-HDAC1/2 Ser423/424
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  HDAC1/2 (Ser423/424) Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies
• Alternative to gene target
  histone deacetylase 1, this GO N-10 and HD1 and RPD3 and RPD3L1, HDAC1 and IDBG-95712 and ENSG00000116478 and 3065, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, HDAC1 and IDBG-644586 and ENSBTAG00000012698 and 404126

Gene info

• Identity
  HGNC:4852
• Gene
  HDAC1
• Long gene name
  histone deacetylase 1
• Synonyms gene
  • RPD3L1
• Synonyms
  • HD1
  • GON-10
  • KDAC1
• GenBank acession
  • D50405
• Locus
  1p35.2-p35.1
• Discovery year
  1996-11-15
• Entrez gene record
  3065
• Pubmed identfication
  • 8602529
• RefSeq identity
  • NM_004964
• Classification
  • NuRD complex subunits
  • Histone deacetylases, class I
  • MiDAC complex subunits
  • EMSY complex
  • SIN3 histone deacetylase complex subunits
• VEGA ID
  OTTHUMG00000007529

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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