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Alternative_name
N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide
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Description
SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibits angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10 μM in biochemical kinase assays.SKLB610 exhibits its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity.
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CAS Number
1125780-41-7
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₂₁H₁₆F₃N₃O₃
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Molecular Weight
415.36
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Cell Permeable
Yes
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Purity
>98% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
A potent angiogenesis inhibitor
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Storage Condition
-20 ̊C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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SMILES
O=C(NC1=CC=C(OC2=CC=NC(C(NC)=O)=C2)C=C1)C3=CC=CC(C(F)(F)F)=C3
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InChi
InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28)
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InChi Key
WACDHHMEVMSODJ-UHFFFAOYSA-N
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MSDS Available
Yes