SKLB610

• Catalog number
  2610-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide
• Description
  SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibits angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10 μM in biochemical kinase assays.SKLB610 exhibits its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity.
• CAS Number
  1125780-41-7
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₆F₃N₃O₃
• Molecular Weight
  415.36
• Cell Permeable
  Yes
• Purity
  >98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent angiogenesis inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• SMILES
  O=C(NC1=CC=C(OC2=CC=NC(C(NC)=O)=C2)C=C1)C3=CC=CC(C(F)(F)F)=C3
• InChi
  InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28)
• InChi Key
  WACDHHMEVMSODJ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SKLB610  
• Short name
  SKLB610
• Alternative name
  SKLB610

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