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HLCL 61 hydrochloride

HLCL 61 hydrochloride is available 4 times from Biovision labs

B1209-5 | HLCL-61 hydrochloride size: 5 mg | 300.67 USD

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B1209-25 | HLCL-61 hydrochloride size: 25 mg | 686.43 USD

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B1209-25 | HLCL-61 hydrochloride for cell activation size: 25 mg | 618.36 USD

Additional description For cells, cell lines and tissues in culture till half confluency.
Short name HLCL-61 hydrochloride for activation
Technique activation
Alternative name HLCL-61 hydrochloride to measure cellular activation
Tissue cell
1. Gene info
Identity5655
Long gene name immunoglobulin heavy variable 4-61
GenBank acession
Discovery year 2000-04-04
Entrez gene record28391
RefSeq identity
Classification
  • Immunoglobulin heavy locus at 14q32.33
Havana BLAST/BLATOTTHUMG00000151976
Additional information
Product images
    #0#.jpegHLCL-61 hydrochloride

B1209-5 | HLCL-61 hydrochloride for cell activation size: 5 mg | 198.56 USD

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Description HLCL-61 is a potent and selective PRMT5 (potent arginine methyltransferase 5) inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members.  In vitro data shows HLCL-61 effectively inhibits symmetric arginine demethylation of histones H3 and H4 in AML samples. HLCL-61 treatment of cells showed decrease in cell vitality and effective in apoptosis promotion in MV-11 and THP-1 cells after 48 hours.
Peptide sequence N/A
CAS number 586395-74-6 (free base). 
Molecular weight 380.92
Category Biochemicals
Other name 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
Molecular formula C₂₃H₂₅ClN₂O 
Physical appearance Crystalline Solid
Supplied with N/A
Is this a salt? Yes
Is it cell-permeable? Yes
Purification ≥98% by HPLC
Reconstitute instructions DMSO(>20 mg/ml)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 36 months
Storage instructions Protect from air and light
Alternate Name/Synonyms 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
Appearance Crystalline Solid
Formulation N/A
CAS Number 586395-74-6 (free base).
Molecular Formula C₂₃H₂₅ClN₂O
Molecular Weight 380.92
Purity ≥98% by HPLC
Solubility/Reconstitution Instructions DMSO(>20 mg/ml)
Handling Protect from air and light
Tagline A selective PRMT5(potent arginine methyltransferase 5) inhibitor
Storage Temp. -20°C
Shipping Conditions gel pack
Shelf Life 36 months
MDL Number N/A
PubChem CID 17208222
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