MK-4101
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Catalog numberB1255-25
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Price:
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Size25 mg
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Alternative_name5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole
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DescriptionMK-4101 is a potent and selective inhibitor of the Hedgehog (Hh) signaling pathway. It displays potent activity against medulloblastoma and Basal Cell Carcinoma (BCC). MK-4101 shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
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CAS Number935273-79-3
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Structure AvailableYes
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Molecular FormulaCâ‚‚â‚„Hâ‚‚â‚„Fâ‚…Nâ‚…O
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Molecular Weight493.48
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineAselective Hedgehog (Hh) signaling pathway inhibitor.
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID16222379
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SMILESCN1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(C5)(F)F)C6=CC=CC=C6C(F)(F)F
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InChiInChI=1S/C24H24F5N5O/c1-34-17(15-4-2-3-5-16(15)24(27,28)29)31-32-20(34)22-9-6-21(7-10-22,8-11-22)19-30-18(35-33-19)14-12-23(25,26)13-14/h2-5,14H,6-13H2,1H3
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InChi KeyHKJOIWLYDJCTQR-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolMVK, STYXL1, MDK, MAPKAPK3, EPCAM
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Short nameMK-4101
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Alternative nameMK-4101
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Gene info
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Identity
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Gene
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Long gene namemevalonate kinase
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Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-10-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameserine/threonine/tyrosine interacting like 1
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Synonyms gene
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Synonyms gene name
- dual specificity phosphatase 24 (putative)
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAP kinase phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemidkine
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Synonyms gene
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Synonyms gene name
- neurite growth-promoting factor 2
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Synonyms
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Locus
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Discovery year1991-07-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMAPK activated protein kinase 3
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Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-03-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MAPK activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameepithelial cell adhesion molecule
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-10-02
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Entrez gene record
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Pubmed identfication
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Classification
- MicroRNA protein coding host genes
- CD molecules
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VEGA ID
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Locus Specific Databases