DCXR, human recombinant

• Catalog number
  P1155-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  Dicarbonyl/L-xylulose reductase, DCR, HCR2, HCRII, KIDCR, P34H
• Alternative_names
  Dicarbonyl/L-xylulose reductase, DCR, HCR2, HCRII, KIDCR, P34H
• Description
  Converts xylulose into xylitol
• Recombinant
  Yes
• Source
  E.coli
• Purity by SDS PAGE
  > 95%
• Assay
  SDS-PAGE
• Activity Specifications test method
  Measured by its ability to oxidize 1 pmole of xylitol to L-xylulose per minute at pH 10 at 37C
• Biological activity
  Specific activity is > 1,800 pmol/min/ug
• Results
  > 1,800 pmol/min/ug
• Molecular Weight
  28 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Liquid
• Physical form description
  In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 20% glycerol, 50 mM NaCl
• Background Information
  Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism of xylulose, converting it into xylitol. DCXR was expressed at low levels and was localized predominantly in the cytoplasmic membrane. In contrast, in virtually all grades of early-stage prostate cancer and in all chemohormonally treated cases, DCXR was strikingly overexpressed and was localized predominantly in the cytoplasm and nucleus. Recombinant human DCXR, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  DCXR  
• Gene symbol
  DCXR-DT, DCXR
• Short name
  DCXR, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  DCXR, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:54083
• Gene
  DCXR-DT
• Long gene name
  DCXR divergent transcript
• Synonyms
  • RP13-650J16.1
• Locus
  17q25.3
• Discovery year
  2018-10-10
• Entrez gene record
  113523640
• Pubmed identfication
  • 30279207
• RefSeq identity
  • NR_159947
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:18985
• Gene
  DCXR
• Long gene name
  dicarbonyl and L-xylulose reductase
• Synonyms gene name
  • dicarbonyl/L-xylulose reductase
• Synonyms
  • KIDCR
  • DCR
  • SDR20C1
  • HCR2
  • P34H
• Synonyms name
  • short chain dehydrogenase/reductase family 20C, member 1
  • human carbonyl reductase 2
  • sperm surface protein P34H
  • kidney dicarbonyl reductase
• GenBank acession
  • AB013846
• Locus
  17q25.3
• Discovery year
  2002-07-25
• Entrez gene record
  51181
• Pubmed identfication
  • 11882650
  • 19027726
• Classification
  • Short chain dehydrogenase/reductase superfamily
• VEGA ID
  OTTHUMG00000178483

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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