SB1518 (Pacritinib)

• Catalog number
  2450-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene
• Description
  A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM) and FLT3 (IC₅₀ = 22 nM). SB1518 displays potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type JAK2 or FLT3, resulting from cell cycle arrest and induction of apoptosis.
• CAS Number
  937272-79-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₈H₃₂N₄O₃
• Molecular Weight
  472.58
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  Apotent JAK2/FLT3 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  46216796
• PubChem CID Link
• SMILES
  C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
• InChi
  InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+
• InChi Key
  HWXVIOGONBBTBY-ONEGZZNKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SB1518   Pacritinib  
• Short name
  SB1518 (Pacritinib)
• Alternative name
  SB1518 (Pacritinib)

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